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Sifan Yin on Muck Rack

Sifan Yin

As seen in: MDPI, BioRxiv, Cell Press, Physical Review B, eLife
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Articles

Biophysical basis for brain folding and misfolding patterns in ferrets and humans

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By Gary Choi, Chunzi Liu, Sifan Yin, RICHARD SMITH
| eLife
eLife Assessment This important study characterizes the morphogenesis of cortical folding in the ferret and human cerebral cortex using complementary physical and computational modeling. Notably, these approaches are applied to charting, in the ferret model, known abnormalities of cortical folding in humans.
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Morphogenesis and morphometry of brain folding patterns across species

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By Sifan Yin, Chunzi Liu, Yeonsu Jung, Katja Heuer
| BioRxiv
Abstract Evolutionary adaptations associated with the formation of a folded cortex in many mammalian brains are thought to be a critical specialization associated with higher cognitive function. The dramatic surface expansion and highly convoluted folding of the cortex during early development is a theme with variations that suggest the need for a comparative study of cortical gyrification.
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Biophysical basis for brain folding and misfolding patterns in ferrets and humans

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By Sifan Yin, Chunzi Liu, Gabrielle Sejourne, Richard Smith
| BioRxiv
Abstract A mechanistic understanding of neurodevelopment requires us to follow the multiscale processes that connect molecular genetic processes to macroscopic cerebral cortical formations and thence to neurological function. Using magnetic resonance imaging of the brain of the ferret, a model organism for studying cortical morphogenesis, we create in vitro physical gel models and in silico numerical simulations of normal brain gyrification.
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