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Sifan Yin on Muck Rack

Sifan Yin

As seen in: MDPI, BioRxiv, Cell Press, Physical Review B, eLife
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Articles

Morphogenesis and morphometry of brain folding patterns across species

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By Sifan Yin, Chunzi Liu, Gary Choi, Yeonsu Jung
| eLife
eLife Assessment This important study presents a cross-species and cross-disciplinary analysis of cortical folding. The authors use a combination of physical gel models, computational simulations, and morphometric analysis, extending prior work in human brain development to macaques and ferrets. The findings support the hypothesis that mechanical forces driven by differential growth can account for major aspects of gyrification.
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Morphogenesis and morphometry of brain folding patterns across species

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By Sifan Yin, Chunzi Liu, Yeonsu Jung, Katja Heuer
| BioRxiv
Abstract Evolutionary adaptations associated with the formation of a folded cortex in many mammalian brains are thought to be a critical specialization associated with higher cognitive function. The dramatic surface expansion and highly convoluted folding of the cortex during early development is a theme with variations that suggest the need for a comparative study of cortical gyrification.
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Biophysical basis for brain folding and misfolding patterns in ferrets and humans

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By Sifan Yin, Chunzi Liu, Gabrielle Sejourne, Richard Smith
| BioRxiv
Abstract A mechanistic understanding of neurodevelopment requires us to follow the multiscale processes that connect molecular genetic processes to macroscopic cerebral cortical formations and thence to neurological function. Using magnetic resonance imaging of the brain of the ferret, a model organism for studying cortical morphogenesis, we create in vitro physical gel models and in silico numerical simulations of normal brain gyrification.
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