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Sik Yin Ho

As seen in: Nature, Stem Cell Reports
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Articles

Enhancing reprogramming towards induced human expanded pluripotency through substitution of SOX2 with engineered SOX17 transcription factors

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By Haoqing Hu, Sik Yin Ho, Mingxi Weng, Degong Ruan, Ralf Jauch, Yuebin Tan
| Nature Verified
Abstract Expanded potential stem cells (EPSCs) represent a distinct and developmentally primitive stem cell population characterized by their broad developmental potential, which encompasses both embryonic and extra-embryonic lineages. In this study, we employed a polycistronic cassette to directly reprogram human fibroblasts into induced Expanded Potential Stem Cells (iEPSCs).
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An acidic residue within the OCT4 dimerization interface of SOX17 is necessary and sufficient to overcome its pluripotency-inducing activity

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By Sik Yin Ho, Haoqing Hu, Mingxi Weng, Andrew Hutchins, Ralf Jauch, Freya Boerner
| Stem Cell Reports Verified
ReportOnline now102398Open access 1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China 2Laboratory for Primate Embryogenesis, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK 3Centre for Translational Stem Cell Biology, Hong Kong SAR, China 4Faculty of Arts and Science, University of Toronto, Toronto, ON, Canada 5Altos Labs, San Diego, CA 92122, USA 6Department of...
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The emergence of Sox and POU transcription factors predates the origins of animal stem cells - Nature Communications

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By Ya Gao, Daisylyn Senna Tan, Mathias Girbig, Qianwen Xie, Sik Yin Ho, Vlad Cojocaru, Jian Yan, Alex de Mendoza
| Nature Verified
Abstract Stem cells are a hallmark of animal multicellularity. Sox and POU transcription factors are associated with stemness and were believed to be animal innovations, reported absent in their unicellular relatives. Here we describe unicellular Sox and POU factors. Choanoflagellate and filasterean Sox proteins have DNA-binding specificity similar to mammalian Sox2.
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