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Simon Hendrik Stitzinger on Muck Rack

Simon Hendrik Stitzinger

As seen in: Cell Press
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Articles

Direct observation of a condensate effect on super-enhancer controlled gene bursting

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By Manyu Du, Freiburg im Breisgau, Jan-Hendrik Spille, Simon Hendrik Stitzinger
| Cell Press Verified
Highlights • Diffraction-sized transcriptional condensate exists in the proximity of Sox2 gene • Condensate enhances gene burst size and frequency when in proximity • Direct anti-correlation between condensate position and gene burst by live imaging • Condensate’s enhancement depends on local/distal genomic elements and cohesin Summary Enhancers are distal DNA elements believed to loop and contact promoters to control gene expression.
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