Simon Johnston
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Professor of Infection Biology #immunolgy #microbiology #mycology #cellbiology #microscopy #autistic they/them
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Articles by Simon Johnston
Harnessing data for global mobility success
Click on the cover to access the digital edition. View your copy of the Autumn 2024 issue of Think Global People magazine. GM teams help assignees thrive in their new roles by setting policies, managing suppliers and maintaining open communication. Yet working to tight budgets and navigating unpredictable markets is no easy task.
Offering Statement [Regulation A]: [Amend]
AN OFFERING STATEMENT PURSUANT TO REGULATION A RELATING TO THESE SECURITIES HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION. INFORMATION CONTAINED IN THIS PRELIMINARY OFFERING CIRCULAR IS SUBJECT TO COMPLETION OR AMENDMENT. THESE SECURITIES MAY NOT BE SOLD NOR MAY OFFERS TO BUY BE ACCEPTED BEFORE THE OFFERING STATEMENT FILED WITH THE COMMISSION IS QUALIFIED.
Islamic Finance And ESG In The UK: An Opportunity For The Taking | IFC Review
24/10/23 Islamic finance remains a relatively niche area of finance in the UK market. Its growth has been reasonably temperate since the 2000s. However, the pressing need to move towards a more sustainable world has seen ESG initiatives come to the forefront of the corporate agenda. We can scarcely get through a week without some new legislative change, government guidance, or environmental catastrophe. This sobering landscape may be the catalyst for Islamic finance to address these challenges.
Ageing-related defects in macrophage function are driven by MYC and USF1 transcriptional programmes
Abstract Macrophages are central innate immune cells whose function declines with age. The molecular mechanisms underlying age-related immunity changes remain poorly understood, particularly in human macrophages. We report a substantial reduction in phagocytosis, migration and chemotaxis in human monocyte-derived macrophages (MDMs) from older (>50 years) compared with younger (18-30 years) donors, alongside downregulation of transcription factors MYC and USF1 with age.
Sustainable Finance and the Goal of Net Zero: what can Islamic finance bring to the table?
The past year has brought a renewed focus on sustainability, both nationally and globally with countries pushing to reduce their reliance on carbon fuel sources and hit their net zero targets. The US Inflation Reduction Act, which is celebrating its first anniversary, has resulted in huge subsidies for renewable and sustainable energy in the US. It has also worried many in the UK renewables sector, particularly given the EU and China’s response by introducing their own green investment policies.
Sustainable Finance and the Goal of Net Zero: what can Islamic finance bring to the table?
Sustainable Finance and the Goal of Net Zero: what can Islamic finance bring to the table? 22/08/2023 The past year has brought a renewed focus on sustainability, both nationally and globally with countries pushing to reduce their reliance on carbon fuel sources and hit their net zero targets. The US Inflation Reduction Act, which is celebrating its first anniversary... Read more Authors Simon Johnston Partner London David Stanbridge Of Counsel Sheffield
Candida albicans cells lacking AP-2 have defective hyphae and are avirulent despite increased host uptake and intracellular proliferation in macrophages
New Results doi: https://doi.org/10.1101/2023.08.03.551781 Abstract Candida albicans is a commensal microbe and opportunistic human pathogen. The yeast can be recognised and taken up by macrophages via interactions with its cell wall, a complex polysaccharide structure containing several components that are specifically recognised by immune cell receptors.
Be aware of the updating requirements for overseas entities at Companies House
31/07/2023 SummaryThe 1st of August 2023 marks the one-year anniversary of the launch of the Register of Overseas Entities (the OE Register) at Companies House and the start of the first annual update process for overseas entities on the register.The Government is also proposing... Read more
Basel 3.1: How calculating risk is changing for banks
The Prudential Regulation Authority (PRA) recently consulted on how it plans to implement the Basel 3.1 standards in the UK. The Basel 3.1 standards are the remaining parts of the Basel III standards that were to be implemented in the UK, which aim to strengthen the regulation, supervision and risk management of banks.
Interest Cover Ratio Default?
Interest Cover Ratio Default? 05/06/2023 Higher global interest rates are continuing to add pressure on borrowers’ ability to comply with interest cover financial covenants and service the interest on their outstanding debt.In this finance briefing we consider the key initial steps and issues for lenders... Read more Authors Simon Johnston Partner London Claudia Guglielmino Associate London Eleanor Abbott Senior Associate London
LMA publishes draft model provisions for Sustainability-Linked Loans
05/05/2023 The LMA has published draft model provisions for sustainability-linked loans (the “SLL Rider”), in response to the rapid growth of sustainability-linked loan issuance in recent years.One of the objectives of the SLL Rider is to better protect the integrity... Read more
Loan to Value default?
20/04/2023 Geopolitical and macroeconomic challenges continue to press the commercial real estate market. In this finance briefing we consider the key initial steps and issues for lenders and borrowers facing a potential default of a loan to value financial covenant in an... Read more
To assign or not to assign - that’s a real question
When taking security over assets, often the default position for lenders has been to take an assignment over assets where they can, in preference to alternative forms of security such as a charge. However, as recent case law has shown, this is not always the most effective approach and can result in unintended consequences.
To assign or not to assign - that’s a real question
13/04/2023 When taking security over assets, often the default position for lenders has been to take an assignment over assets where they can, in preference to alternative forms of security such as a charge. However, as recent case law has shown, this is not always the most... Read more
Basel 3.1: How calculating risk is changing for banks
04/07/2023 The Prudential Regulation Authority (PRA) recently consulted on how it plans to implement the Basel 3.1 standards in the UK. The Basel 3.1 standards are the remaining parts of the Basel III standards that were to be implemented in the UK, which aim to strengthen... Read more
Re Avanti Communications Ltd (2023): fixed v floating charge - a spectrum of control?
04/05/2023 This briefing considers the recent case of Re Avanti Communications Ltd [2023] EWHC 940 (Ch) in which the English Court considered what was required to characterise a fixed charge, rather than a floating charge and the degree of control necessary to have a fixed... Read more
Leon v Kensington Mortgage Company Ltd & Anor (2023) and the concept of subrogation
30/03/2023 This briefing considers the concepts of "subrogation" and "bona vacantia" which were discussed in the recent case of Leon v Kensington Mortgage Company Ltd & Anor [2023] EWHC 121 (Ch). Where a surety or guarantor has to make a payment of the liabilities it has... Read more
Important deadline imminent for Economic Crime Act
Summary The Economic Crime (Transparency and Enforcement) Act 2022 has set up a new Companies House register for overseas entities that own certain property registered at the Land Registry in England and Wales or the Land Registers of Scotland or Northern Ireland. The Companies House register contains information about the entity and its beneficial owners and the Act impacts on real estate transactions and their registration.
I’m Quitting-This Bowling Alley Is Going to Have to Find a New CGI Skeleton to Go On-Screen After a Strike
Hey Ronnie, you got a second? I want to talk to you about some issues I’m having out on the floor. Now, let me make this abundantly clear. I didn’t take this job because I wanted to be a star, and I don’t want more cash or anything. You knew when you hired me that I didn’t want this job because of the money. Just like how I knew when I got into this business that screen time was never guaranteed. But Ron, It’s been almost a year since I got to go out there and I need to perform.
Car Insurance The General vs. Dracula with Jon Barr on Apple Podcasts
57 min Jon Barr (@JonBarrTweets, Twitch) steps into Film Nerd Studios to talk about Car Insurance The General vs. Dracula, what was once the first film in a larger car insurance mascot cinematic universe. We discuss the special effects used to turn Idris Elba into the Geico Gecko, writer Tony Desantis's interesting choices, and our time at the Aaron Sorkin and Ron Howard Masterclasses. Plus, we step into the Writer's Room to rewrite a kids classic, Flubber.
A Glucuronoxylomannan Epitope Exhibits Serotype-Specific Accessibility and Redistributes towards the Capsule Surface during Titanization of the Fungal Pathogen Cryptococcus neoformans
Fungal and Parasitic Infections | Spotlight Mark Probert, Xin Zhou, Margaret Goodall, Simon A. Johnston, Ewa Bielska, Elizabeth R. Ballou, Robin C. May George S. Deepe, Editor DOI: 10.1128/IAI.00731-18 ABSTRACT Disseminated infections with the fungal species Cryptococcus neoformans or, less frequently, Cryptococcus gattii are an important cause of mortality in immunocompromised individuals.
Inhibition of Classical and Alternative Modes of Respiration in Candida albicans Leads to Cell Wall Remodeling and Increased Macrophage Recognition
Research Article | Host-Microbe Biology Lucian Duvenage, Louise A. Walker, Aleksandra Bojarczuk, Simon A. Johnston, Donna M. MacCallum, Carol A. Munro, Campbell W. Gourlay Ana Traven, Invited Editor, Judith Berman, Editor DOI: 10.1128/mBio.02535-18 ABSTRACT The human fungal pathogen Candida albicans requires respiratory function for normal growth, morphogenesis, and virulence. Mitochondria therefore represent an enticing target for the development of new antifungal strategies.
What is a pulsar? Marking 50 years since their discovery by Jocelyn Bell
A pulsar is a small, spinning star—a giant ball of neutrons, left behind after a normal star has died in a fiery explosion. With a diameter of only 30km (18.6 miles), the star spins up to hundreds of times a second, while sending out a beam of radio waves (and sometimes other radiation, such as X-rays). When the beam is pointed in our direction and into our telescopes, we see a pulse. 2017 marks 50 years since pulsars were discovered.
Fifty Years Ago Jocelyn Bell Discovered Pulsars and Changed Our View of the Universe - The Wire
A pulsar is a small, spinning star – a giant ball of neutrons, left behind after a normal star has died in a fiery explosion. With a diameter of only 30 km, the star spins up to hundreds of times a second, while sending out a beam of radio waves (and sometimes other radiation, such as X-rays). When the beam is pointed in our direction and into our telescopes, we see a pulse. 2017 marks 50 years since pulsars were discovered.
Fifty years ago, Jocelyn Bell discovered pulsars and changed our view of the universe
With a diameter of only 30 km, the star spins up to hundreds of times a second, while sending out a beam of radio waves (and sometimes other radiation, such as X-rays). When the beam is pointed in our direction and into our telescopes, we see a pulse. 2017 marks 50 years since pulsars were discovered.
The Importance of End-to-End Encryption in Protecting Your Information
WhatsApp recently added end-to-end encryption to its instant messaging app. If you have this app, you would have noticed the following messages on your open chats: WhatsApp explains the motivation behind this new feature on its blog: “When you send a message, the only person who can read it is the person or group chat that you send that message to. No one can see inside that message. Not cyber criminals. Not hackers. Not oppressive regimes. Not even us.
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