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Articles by Simone Cesaro
Invasive mold infection in pediatric acute lymphoblastic leukemia—a detailed analysis of the clinical trial AIEOP-BFM ALL2009
To the Editor: Invasive fungal disease (IFD) is an important cause of morbidity in immunocompromised children and negatively impacts overall outcome [1].
Early software-assisted response predicts survival in a prospective cohort of 258 newly diagnosed cGvHD patients
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Abstract Two hundred and fifty-eight patients with newly diagnosed cGVHD have been enrolled in a multicenter study (NCT02991846). Primary endpoint was failure free survival (FFS); secondary endpoints were ORR at 6 and 12 months after best available therapy (BAT) and OS. Response evaluation was supported by a software (Crosy) collecting cGvHD master data.
By Attilio Olivieri, Giorgia Mancini, Jacopo Olivieri, Francesco Saraceni, Luisa Giaccone, Alessandra Algarotti, Giuseppe Milone, Salvatore Leotta, Maura Faraci, Fabio Benedetti, Simone Cesaro, Franca Fagioli, Francesco Saglio, Irene Cavattoni, Anna Mele, Chiara Nozzoli, Domenico Russo, Michele Malagola, Daniele Vallisa, Giulia Prunotto, Francesca Patriarca, Antonella Geromin, Edoardo Benedetti, Nicola Mordini, Francesco Merli, Massimo Martino, Francesca Bonifazi, Selene Guerzoni, Irene Federici, Maria Caterina Micò, Jacopo Peccatori, Mario Arpinati, Carlo Borghero
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Nature
Verified
Central nervous system complications after allogeneic haematopoietic cell transplantation: best practice recommendations from the EBMT practice harmonisation and guidelines committee on epidemiology, outcome and neuroimaging
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Abstract CNS complications (CNSC) may occur in a significant proportion of patients after allogeneic haematopoietic cell transplantation (allo-HCT). They can be differentiated into infectious and non-infectious CNSC, such as vascular pathologies (e.g., bleeding, stroke), drug-related abnormalities, and CNS relapse of the underlying malignancy.
By Martin Schmidt-Hieber, Roser Velasco, Olaf Penack, Dina Averbuch, Aitana Balaguer-Roselló, Francesco Baccelli, Luis Bataller, Simone Cesaro, Chiara Briani, Rafael de la Camara, Petra Huehnchen, Thushan de Silva, Alberto Mussetti, Per Ljungman, Zinaida Perić, Malgorzata Mikulska, Alexey Polushin, David Navarro Verified, Albert Pons-Escoda, Dionysios Neofytos, Helene M. Schoemans, José Luis Piñana, Francesco Onida, Annalisa Ruggeri, Isabel Sánchez-Ortega, Ibrahim Yakoub-Agha, Jan Styczynski
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Nature
Verified
Symptom-guided approach to central nervous system complications in allogeneic hematopoietic cell transplant recipients: Best practice recommendations from the EBMT Practice Harmonisation and Guidelines committee
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Abstract Central nervous system complications (CNSC) after allogeneic hematopoietic cell transplantation (allo-HCT) are relatively common and may have a major impact on patients´ outcomes. Neurological symptoms may occur at any point during the post-transplant course, although they are more common early after HCT, with a wide range of possible presentations.
By Roser Velasco, Martin Schmidt-Hieber, Olaf Penack, Dina Averbuch, Aitana Balaguer-Roselló, Francesco Baccelli, Luis Bataller, Simone Cesaro, Chiara Briani, Rafael de la Camara, Petra Huehnchen, Thushan de Silva, Alberto Mussetti, Per Ljungman, Zinaida Perić, Malgorzata Mikulska, David Ortega Verified, Albert Pons-Escoda, Dionysios Neofytos, Helene M. Schoemans, José Luis Piñana, Francesco Onida, Annalisa Ruggeri, Isabel Sánchez-Ortega, Ibrahim Yakoub-Agha, Jan Styczynski, Alexey Polushin
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Nature
Verified
Impact of donor and recipient EBV serostatus on transplant outcomes in patients with acute leukemia after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide: Infectious Diseases Working Party EBMT retrospective study
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Allogeneic hematopoietic cell transplantation (allo-HCT), including haploidentical HCT (haplo-HCT) is a potentially curative therapy that shows encouraging long-term outcomes in hematological diseases [1,2,3,4]. In prior studies and meta-analyses, donor and recipient Epstein-Barr virus (EBV) seropositivity has been shown to significantly impact transplant outcomes after allo-HCT [5,6,7,8].
By Jan Styczynski, Gloria Tridello, Inge Verheggen, Nina Knelange, Lotus Wendel, Per Ljungman, José Luis Piñana, Malgorzata Mikulska, Lidia Gil, Simone Cesaro, Fabio Ciceri, Raffaella Greco, Depei Wu, Didier Blaise, Raffaella Cerretti, Patrice Chevallier, Edouard Forcade, Flore Sicre de Fontbrune, Mohamad Mohty Verified, Claude Eric Bulabois, Stéphanie Nguyen Quoc, Ibrahim Yakoub-Agha, Rafael de la Camara, Dina Averbuch, Sophie Ducastelle Lepretre
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Nature
Verified
Incidence and outcome of hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: a survey of the infectious diseases working party of EBMT
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Hemorrhagic cystitis (HC) is a frequent complication after hematopoietic cell transplant (HCT), with an incidence ranging from 2 to 66% depending on the type of transplant and the age of the patient [1,2]. In the last two decades, the use of post-transplant cyclophosphamide (PT-Cy) as graft-versus-host-disease (GVHD) prophylaxis has been associated with an increased incidence of HC [3,4].
By Simone Cesaro, Chiara Garonzi, Gloria Tridello, Inge Verheggen, Daihong Liu, Catherine Flynn, Ali Alahmari, Leylagül Kaynar, Werner Rabitsch, Vedat Uygun, Pedro Chorão, Jiong Hu, Albert Esquirol, José Luis Piñana, Mahmoud Aljurf, Eva Wagner-Drouet, Peter Lang, Guillermo Martín-Sánchez, Barbara Nasilowska-Adamska, Jan Styczynski, Ron Ram, Elisabetta Metafuni, Alina Doina Tanase, Krzysztof Kalwak, Bianca Serio, Hasan Hashem, Luca Castagna, Marta González Vicent, Musa Karakukcu, Ioannis Baltadakis, Edoardo Benedetti, Malgorzata Mikulska, Rafael de la Camara, Dina Averbuch, Siret Ratip, Luca Facchini, Khaled Halahleh
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Nature
Verified
Length of SARS-CoV-2 shedding in HCT recipients: an Infectious Disease Working Party of EBMT study - Bone Marrow Transplantation
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COVID-19 has been associated with increased morbidity and mortality in immunocompromised patients due to inadequate control of the virus, resulting in higher risk of progression to severe disease, clinical and virological relapses and long time to viral elimination [1, 2]. Prolonged shedding of SARS-CoV-2 can also lead to delays in treatment of the underlying disease and viral evolution with the development of resistance [3,4,5].
By Malgorzata Mikulska, Gloria Tridello, Per Ljungman, Jan Styczynski, Diana Averbuch, Simone Cesaro, Nina Knelange, José Luis Piñana, Marina Popova, Nicolaus Kröger, Henrik Sengeloev, Caroline Besley, Hélène Labussiere-Wallet, Zeynep Yegin, Raffaella Greco, Frédéric Baron, Ipek Yonal-Hindilerden, Aliénor Xhaard, Elisabetta Metafuni, Jennifer Byrne, Selami Koçak Toprak, Anna Grassi, Daniele Vallisa, Jennifer Clay, Rodrigo Martino Bufarull, Gwendolyn van Gorkom, Omur Gokmen Sevindik, Keith Wilson, Lotus Wendel, Mareike Verbeek, Rafael de la Camara
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Nature
Verified
Invasive yeast infection in paediatric acute lymphoblastic leukaemia: A report from the multi‐international clinical trial AIEOP‐BFM ALL 2009
To the Editor, Invasive fungal diseases (IFDs) remain important causes for infectious morbidity in immunocompromised children and adolescents with a negative impact upon overall survival.1, 2 Regrettably, however, most analyses of IFDs in paediatric patient populations at risk are limited by their restriction to individual centres, differences in IFD definitions, population denominators and fungal pathogens included, and systematic large-scale data on the incidence, presentation and outcome...
Defibrotide for prophylaxis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) in pediatric high-risk patients: consensus guidelines from the European Society for Blood and Marrow Transplantation (EBMT) | Bone Marrow Transplantation
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Abstract SOS/VOD is a life-threatening complication of hematopoietic stem cell transplantation, especially in children, with incidences reaching up to 15–20%. Despite efforts, SOS/VOD remains unpredictable with significant morbidity and mortality. High-risk criteria are clearly defined, and the pediatric EBMT diagnostic criteria have improved sensitivity, reducing treatment delays and enhancing outcomes.
By Selim Corbacioglu, Rajinder Bajwa, Ali Bülent Antmen, Adriana Balduzzi, Jaap Jan Boelens, Simone Cesaro, Fabio Ciceri, Antonio Colecchia, Katharina Kleinschmidt, Kris M. Mahadeo, Antonio Pagliuca, Peter Shaw, Jerry Stein, Zofia Szmit, Elif Ince, Marta Verna, Marco Zecca, Paul Richardson, Krzysztof Kalwak, Akif Yesilipek
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Nature
Verified
Ataluren improves hematopoietic and pancreatic disorders in Shwachman-Diamond syndrome patients: a compassionate program case-series - Nature Communications
Abstract Shwachman-Diamond syndrome (SDS) is characterized by exocrine pancreatic insufficiency, neutropenia, and a high risk of myeloid malignancy. Most patients with SDS harbor nonsense mutations in Shwachman-Bodian-Diamond syndrome gene (SBDS), which encodes a ribosome assembly factor. We investigated the translational read-through effect of ataluren in three patients with SDS undergoing a compassionate use program for twelve months.
A survey on the practices and the management of hemorrhagic cystitis in patients who undergo allogeneic hematopoietic stem cell transplantation, on behalf of the Infectious Diseases Working Party of EBMT | Bone Marrow Transplantation
Abstract This survey reports on the current practice and management of hemorrhagic cystitis (HC) among the EBMT centers. The survey response rate was 27%. The diagnostic search of BK polyomavirus (BKPyV) was available in 93% of centers and performed in urine (100%), blood/plasma (51%), and serum (12%). Patient screening for BKPyV infection was performed in 14% of centers before hematopoietic cell transplantation (HCT).
Author’s Reply to the correspondence: ECIL-10 guidelines for COVID-19 should take convalescent plasma into proper consideration by Focosi et al. - Leukemia
In their letter, Focosi et al. present some observations and question our recommendations regarding the use of high-titre convalescent plasma (CP) presented in the recent guidelines on COVID-19 issued by the 10th European Conference on Infections in Leukaemia (ECIL 10) held in September 2024 [1, 2]. The ECIL reviews the published literature and makes recommendations based on the available evidence.
Post-pandemic recommendations for the management of COVID-19 in patients with haematological malignancies or undergoing cellular therapy, from the European Conference on Infections in Leukaemia (ECIL-10) | Leukemia
Abstract In the post-pandemic years, SARS-CoV-2 morbidity and mortality declined due to less pathogenic variants, active and passive immunization, and antiviral therapies. However, patients with hematological malignancies and/or undergoing hematopoietic cell transplantation (HCT) remain at increased risk for poor outcomes. Therefore, adherence to contact and droplet precautions is essential to avoid transmission, especially during epidemic waves.
Diagnostic accuracy of liver stiffness measurement for the diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome after hematopoietic stem cell transplantation (HSCT), the ELASTOVOD STUDY: an investigator-initiated, prospective, multicentre d
Abstract Hepatic Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a severe complication following hematopoietic stem cell transplantation (HSCT), traditionally diagnosed based on clinical criteria. This study aimed to evaluate the diagnostic performance of liver stiffness measurement (LSM) as a non-invasive tool for non invasive diagnosis of VOD/SOS. A multicentre clinical trial was conducted in Italy from April 2018 to December 2021, screening 1089 patients across 25 centers.
Adenovirus infections after allogeneic hematopoietic cell transplantation in children and adults: a study from the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation | Bone Marrow Transplantation
Abstract The objective of the study was the analysis of clinical types, outcomes, and risk factors associated with the outcome of adenovirus (ADV) infection, in children and adults after allo-HCT. A total number of 2529 patients (43.9% children; 56.1% adults) transplanted between 2000 and 2022 reported to the EBMT database with diagnosis of ADV infection were analyzed. ADV infection manifested mainly as viremia (62.6%) or gastrointestinal infection (17.9%).
An expert consensus on prevention, diagnosis, and management of hemorrhagic cystitis in pediatric hematopoietic cell transplantation, on behalf of the Infectious Disease and Hematopoietic Cell Transplant Working groups of Italian Pediatric Hematology Onco
Abstract The optimal management of hemorrhagic cystitis (HC) in hematopoietic stem cell transplantation (HCT) is debated, both for early onset HC (EOHC) secondary to chemotherapy toxicity and BK Polyomavirus (BKPyV)-related HC, due to the lack of controlled trials, particularly referred to pediatric setting.
Prevalence, management, and new treatment modalities of EBV-DNA-emia and EBV-PTLD after allo-HCT: survey of Infectious Diseases Working Party EBMT - Bone Marrow Transplantation
Abstract The aim of this study was to determine the current approach of EBV-driven post-transplant complications in context of monitoring, diagnosis, prevalence and treatment in EBMT transplant centers. Routine serology testing in patient and donor before HCT is performed in 95.5% centers. Pretransplant EBV-DNA is routinely tested in all patients in 32.7% centers. Monitoring for EBV infection is feasible in 98.2% centers: including 66.7% centers using standardized PCR.
Adenovirus infection in allogeneic hematopoietic cell transplantation
REFERENCES 1. Human adenovirus infections in pediatric population—an update on clinico-pathologic correlation. Biomed J. 2022; 45(1): 38-49. doi:10.1016/j.bj.2021.08.009 2, . Adenovirus: epidemiology, global spread of novel serotypes, and advances in treatment and prevention. Semin Respir Crit Care Med. 2016; 37(4): 586-602. doi:10.1055/s-0036-1584923 3, , .
Update of recommendations for the management of COVID-19 in patients with haematological malignancies, haematopoietic cell transplantation and CAR T therapy, from the 2022 European Conference on Infections in Leukaemia (ECIL 9) | Leukemia
In 2022, the European Conference on Infections in Leukemia, 9th edition (ECIL-9), published the guidelines for the management of severe acute respiratory syndrome infection (SARS-CoV-2) and disease (COVID-19) in hematological malignancy (HM) and haematopoietic cell transplant (HCT) patients [1].
Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT | Bone Marrow Transplantation
Authors and Affiliations Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Torun, Bydgoszcz, Poland Jan Styczynski Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy Gloria Tridello & Simone Cesaro EBMT Leiden Study Unit, Leiden, The Netherlands Gloria Tridello, Linda Koster, Nina Knelange, Lotus Wendel, Anja van Biezen & Steffie van der Werf Division of Infectious...
Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period: a prospective multinational Infectious Disease Working Party from the European Society for Blood and Mar
Authors and Affiliations Faculty of Medicine, Hebrew University of Jerusalem, Pediatric Infectious Diseases, Hadassah Medical Center, Jerusalem, Israel Dina Averbuch Hematology Department, Hospital Universitario de La Princesa, Madrid, Spain Rafael de la Camara Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy Gloria Tridello & Simone Cesaro EBMT - Leiden Study Unit, Leiden, Netherlands Nina Simone Knelange RM Gorbacheva...
Invasive fungal diseases impact on outcome of childhood ALL – an analysis of the international trial AIEOP-BFM ALL 2009 - Leukemia
Abstract In children with acute lymphoblastic leukemia (ALL), risk groups for invasive fungal disease (IFD) with need for antifungal prophylaxis are not well characterized, and with the advent of new antifungal compounds, current data on outcome are scarce.
Recommendations for the management of COVID-19 in patients with haematological malignancies or haematopoietic cell transplantation, from the 2021 European Conference on Infections in Leukaemia (ECIL 9) | Leukemia
Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel virus that spread worldwide from 2019 causing the Coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 infection is characterised by an initial viral phase followed in some patients by a severe inflammatory phase. Importantly, immunocompromised patients may have a prolonged viral phase, shedding infectious viral particles for months, and absent or dysfunctional inflammatory phase.
A Prospective Study of Hematologic Complications and Long-Term Survival of Italian Patients Affected by Shwachman-Diamond Syndrome
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Figure 1 OS of 121 patients enrolled in the RI-SDS. Figure 2 EFS of 121 patients enrolled in the RI-SDS. Objective To describe the hematologic outcome and long-term survival of patients enrolled in the Shwachman-Diamond syndrome Italian Registry.
Vaccination of patients with haematological malignancies who did not have transplantations: guidelines from the 2017 European Conference on Infections in Leukaemia (ECIL 7)
Chisholm JC Devine T Charlett A Pinkerton CR Zambon M Response to influenza immunisation during treatment for cancer. Arch Dis Child. 2001; 84: 496-500 Cooksley CD Avritscher EB Bekele BN Rolston KV Geraci JM Elting LS Epidemiology and outcomes of serious influenza-related infections in the cancer population. Cancer. 2005; 104: 618-628 Kyaw MH Rose Jr, CE Fry AM et al. The influence of chronic illnesses on the incidence of invasive pneumococcal disease in adults. J Infect Dis.
A survey on hematology-oncology pediatric AIEOP centres: the challenge of posterior reversible encephalopathy syndrome
Posterior reversible encephalopathy syndrome (PRES) is one of the most common neurological complications in hematology-oncology pediatric patients. Despite an increasingly recognized occurrence, no clear consensus exists regarding how best to manage the syndrome, because most cases of PRES have reported in single case reports or small series.
Retrospective study on the incidence and outcome of proven and probable invasive fungal infections in high-risk pediatric onco-hematological patients
invasive fungal infection (IFI) is a cause of morbidity, mortality and increased health costs in children undergoing chemotherapy or hematopoietic stem cell transplant (HSCT). multi-center, retrospective study to assess the incidence, outcome of proven and probable IFI (PP-IFI) in children treated for acute leukemia, non-Hodgkin lymphoma or who underwent HSCT from 2006 to 2012. Over the 7-year period, 127 PP-IFI were diagnosed in 123 patients, median age of 9.7 years.
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