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Articles by Simone Pecetta
Broadly protective mucosal vaccination in the respiratory tract
Mucosal vaccination can raise the immunological readiness of the respiratory tract before pathogen exposure, potentially enabling protection beyond antigen-specific immunity.
Viral evolution prediction identifies broadly neutralizing antibodies to existing and prospective SARS-CoV-2 variants - Nature Microbiology
Abstract Monoclonal antibodies (mAbs) targeting the SARS-CoV-2 receptor-binding domain are used to treat and prevent COVID-19. However, the rapid evolution of SARS-CoV-2 drives continuous escape from therapeutic mAbs. Therefore, the ability to identify broadly neutralizing antibodies (bnAbs) to future variants is needed. Here we use deep mutational scanning to predict viral receptor-binding domain evolution and to select for mAbs neutralizing both existing and prospective variants.
The evolving landscape of live attenuated COVID-19 vaccines - Nature Microbiology
A genetic approach based on the introduction of premature termination codons can attenuate SARS-CoV-2 and induce protective mucosal immunity.
Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41 - Nature Immunology
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Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01833-w, published online 30 May 2024 In the version of the article initially published, Steven Schultze’s surname appeared incorrectly (as Schulze) and has now been amended in the HTML and PDF versions of the article.
By Ivy Phung, Olivia K. Swanson, Chang-Chun D. Lee, Ester Marina-Zárate, Gabriel Ozorowski, Kimmo Rantalainen, Joel Allen, Sabyasachi Baboo, Oscar Rodriguez, Oscar Rodríguez Verified, Óscar Rodríguez Verified, Sunny Himansu, Swati Saha, Simone Pecetta, Ying-Cing Lin, Jordan Willis, Daniel Kulp, Christopher A. Cottrell, Oleksandr Kalyuzhniy, Erik Georgeson, Rama R. Amara, Elise Landais, Dennis R. Burton, Guido Silvestri, Corey T. Watson, James C. Paulson, Max Crispin, Gevorg Grigoryan, Andrew Ward, Devin Sok, Frederick W. Alt, Ian Wilson, Facundo D. Batista, Shane Crotty
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Nature
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Affinity gaps among B cells in germinal centers drive the selection of MPER precursors - Nature Immunology
Abstract Current prophylactic human immunodeficiency virus 1 (HIV-1) vaccine research aims to elicit broadly neutralizing antibodies (bnAbs). Membrane-proximal external region (MPER)-targeting bnAbs, such as 10E8, provide exceptionally broad neutralization, but some are autoreactive. Here, we generated humanized B cell antigen receptor knock-in mouse models to test whether a series of germline-targeting immunogens could drive MPER-specific precursors toward bnAbs.
Vaccination induces broadly neutralizing antibody precursors to HIV gp41 - Nature Immunology
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Abstract A key barrier to the development of vaccines that induce broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic diversity is the design of priming immunogens that induce rare bnAb-precursor B cells.
By Ivy Phung, Olivia K. Swanson, Chang-Chun D. Lee, Ester Marina-Zárate, Gabriel Ozorowski, Kimmo Rantalainen, Joel Allen, Sabyasachi Baboo, Oscar Rodriguez, Oscar Rodríguez Verified, Óscar Rodríguez Verified, Sunny Himansu, Swati Saha, Simone Pecetta, Ying-Cing Lin, Jordan Willis, Daniel Kulp, Christopher A. Cottrell, Oleksandr Kalyuzhniy, Erik Georgeson, Rama R. Amara, Elise Landais, Dennis R. Burton, Guido Silvestri, Corey T. Watson, James C. Paulson, Max Crispin, Gevorg Grigoryan, Andrew Ward, Devin Sok, Frederick W. Alt, Ian Wilson, Facundo D. Batista, Shane Crotty
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Nature
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Vaccines for a sustainable planet
Current Issue There are no results at this time LATEST NEWS Abstract The health of the planet is one objective of the United Nations’ Sustainable Development Goals. Vaccines can affect not only human health but also planet health by reducing poverty, preserving microbial diversity, reducing antimicrobial resistance, and preventing an increase in pandemics that is fueled partly by climate change.
Global antibiotic use during the COVID-19 pandemic: analysis of pharmaceutical sales data from 71 countries, 2020-2022
Summary Background Despite bacterial coinfection rates of less than 10%, antibiotics are prescribed to an estimated 75% of patients with COVID-19, potentially exacerbating antimicrobial resistance. We estimated the associations of COVID-19 cases and vaccinations with global antibiotic sales during the first two years of the COVID-19 pandemic.
Vaccines 2020: The era of the digital vaccine is here
Mariagrazia Pizza https://orcid.org/0000-0002-7800-1404, Simone Pecetta https://orcid.org/0000-0001-9898-4324, and Rino Rappuoli https://orcid.org/0000-0002-8827-254X Abstract REFERENCES AND NOTES Abstract The SARS-CoV-2 pandemic has generated a renaissance in vaccinology, with COVID-19 mRNA vaccines delivering a “digital code” of the viral antigen with no need to purify proteins or inactivate pathogens.
Antibodies, epicenter of SARS-CoV-2 immunology
Antibodies against SARS-CoV-2 are the epicenter of the efforts to understand and fight the COVID-19 pandemic. They play a central role in clearing the virus from infected patients, they are key reagents of rapid diagnostics, they are first line treatments for hospitalized COVID-19 patients and they are the main objective of COVID-19 vaccine development.
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