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Ying-Cing Lin

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Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41 - Nature Immunology

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By Ivy Phung, Olivia K. Swanson, Chang-Chun D. Lee, Ester Marina-Zárate, Gabriel Ozorowski, Kimmo Rantalainen, Joel Allen, Sabyasachi Baboo, Oscar Rodriguez, Oscar Rodríguez Verified, Óscar Rodríguez Verified, Sunny Himansu, Swati Saha, Simone Pecetta, Ying-Cing Lin, Jordan Willis, Daniel Kulp, Christopher A. Cottrell, Oleksandr Kalyuzhniy, Erik Georgeson, Rama R. Amara, Elise Landais, Dennis R. Burton, Guido Silvestri, Corey T. Watson, James C. Paulson, Max Crispin, Gevorg Grigoryan, Andrew Ward, Devin Sok, Frederick W. Alt, Ian Wilson, Facundo D. Batista, Shane Crotty
| Nature Verified
Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01833-w, published online 30 May 2024 In the version of the article initially published, Steven Schultze’s surname appeared incorrectly (as Schulze) and has now been amended in the HTML and PDF versions of the article.
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Affinity gaps among B cells in germinal centers drive the selection of MPER precursors - Nature Immunology

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By Kimmo Rantalainen, Shivang Parikh, Raphael A. Reyes, Ying-Cing Lin, Simone Pecetta, Sophie Giguère, Olivia K. Swanson, Sven Kratochvil, Eleonora Melzi, Ivy Phung, Oleksandr Kalyuzhniy, Erik Georgeson, Shane Crotty, Ian Wilson, William R. Schief
| Nature Verified
Abstract Current prophylactic human immunodeficiency virus 1 (HIV-1) vaccine research aims to elicit broadly neutralizing antibodies (bnAbs). Membrane-proximal external region (MPER)-targeting bnAbs, such as 10E8, provide exceptionally broad neutralization, but some are autoreactive. Here, we generated humanized B cell antigen receptor knock-in mouse models to test whether a series of germline-targeting immunogens could drive MPER-specific precursors toward bnAbs.
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Vaccination induces broadly neutralizing antibody precursors to HIV gp41 - Nature Immunology

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By Ivy Phung, Olivia K. Swanson, Chang-Chun D. Lee, Ester Marina-Zárate, Gabriel Ozorowski, Kimmo Rantalainen, Joel Allen, Sabyasachi Baboo, Oscar Rodriguez, Oscar Rodríguez Verified, Óscar Rodríguez Verified, Sunny Himansu, Swati Saha, Simone Pecetta, Ying-Cing Lin, Jordan Willis, Daniel Kulp, Christopher A. Cottrell, Oleksandr Kalyuzhniy, Erik Georgeson, Rama R. Amara, Elise Landais, Dennis R. Burton, Guido Silvestri, Corey T. Watson, James C. Paulson, Max Crispin, Gevorg Grigoryan, Andrew Ward, Devin Sok, Frederick W. Alt, Ian Wilson, Facundo D. Batista, Shane Crotty
| Nature Verified
Abstract A key barrier to the development of vaccines that induce broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic diversity is the design of priming immunogens that induce rare bnAb-precursor B cells.
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