Simone Tambaro

Abstract Specialized intramembrane proteases, known as iCLiPs, regulate the processing of transmembrane proteins by releasing intracellular domains, which can function as transcriptional regulators. The signal peptide peptidase–like (SPPL) family of iCLiPs, particularly SPPL2b, has roles in immune regulation, neuronal function, and disease pathogenesis. In the brain, SPPL2b localizes mainly in the plasma membrane of neurons and microglia and is abundant in the cortex and hippocampus.

Simone Tambaro, Lorena Galan-Acosta, Axel Leppert, Gefei Chen, Henrik Biverstål, Jenny Presto, Per Nilsson and Jan Johansson1 From the Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 141 83 Huddinge, Sweden ↵1 To whom correspondence should be addressed. E-mail: janne.johansson{at}ki.se.

Simone Tambaro1, Lorena Galán-Acosta1, Axel Leppert1, Gefei Chen1, Henrik Biverstål2, Jenny Presto3, Per Nilsson1 and Jan Johansson1* 1Karolinska Institutet, Sweden 2Karolinska Institutet 3Neurobiology, care sciences and society, Karolinska Institutet, Sweden ↵* Corresponding author; email: janne.johansson{at}ki.se Author contributions: S.T., L.G.-A., A.L., G.C., H.B., and P.N. data curation; S.T., J.P., and J.J. formal analysis; S.T., L.G.-A., A.L., G.C., H.B., and P.N. investigation; S.T....