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Simone Wegen

As seen in: MDPI, Cell Press
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Articles by Simone Wegen

Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients

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By Jianzhou Chen, Antonin Levy, Guoxin Cai, Marine Fidelle, Conrad Rauber, Pierre Ly, Gianmarco Piccinno, Peng Liu, Sylvère Durand, Misha Mao, Liwei Zhao, Valerio Iebba, Hannah Felchle, Julius Clemens Fischer, Simon Thomas, Tim F. Greten, Jennifer Jones, Cecilia Monge, Sandra Demaria, Silvia C. Formenti, Lorenzo Belluomini, Christophe Massard, Pierre Blanchard, Michele Mondini, Lydia Meziani, Yizhou Zhan, Daphné Morel, Roger Sun, Monica Mangoni, Vanessa Di Cataldo, Maike Trommer, Simone Wegen, Rachel P. Riechelmann, Pierre-Edouard Fournier, Nicola Segata, Peter Holicek, Lorenzo Galluzzi, Aitziber Buqué, Lisa Derosa, Guido Kroemer, Laurence Zitvogel, Eric Deutsch, Ai-Ling Tian, Xuehan Huang, Eugénie Pizzato, Lisa Sitterle, Valeria Dionisi, Charlotte Robert, Clément Quevrin, Eloise Lopes, Céline Clémenson, Chengbing Zeng, Qingxin Cai, Pierre-Antoine Laurent, Chiara Arilli, Sebastian Neppl, Marcos P. Camandaroba, Elson Santos Neto, Chuangzhen Chen
| Cell Press Verified
Keywords: cancer radiotherapy gut microbiota Christensenella minuta bile acids dendritic cells tumor immunosurveillance metabolomics Introduction Preclinical models suggest that the combination of radiotherapy (RT), including stereotactic ablative radiotherapy (SABR) and immune checkpoint blockade (ICB), mediates synergistic anti-tumor immune responses not only at the local site but also on distal, non-irradiated tumors, known as “abscopal” effects.1,2,3 Hundreds of trials, including ours,...
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Cancers | Free Full-Text | The Role of Age and Comorbidities in Esophagogastric Cancer Chemoradiation of the Frail Elderly (>70 Years): An Analysis From a Tertiary High Volume-Center

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By Anne Adams, Simone Wegen, Philipp Linde, Markus Mallmann
| MDPI
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
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Low Temperature and Neutral pH Define “Candidatus Nitrotoga sp.” as a Competitive Nitrite Oxidizer in Coculture with Nitrospira defluvii

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By Simone Wegen, Boris Nowka, Eva Spieck
| asm.org
Environmental Microbiology Simone Wegen, Boris Nowka, Eva Spieck Shuang-Jiang Liu, Editor DOI: 10.1128/AEM.02569-18 ABSTRACT Nitrification is an essential process for N removal in activated sludge to avoid toxicity of ammonium and nitrite. Besides Nitrospira, “Candidatus Nitrotoga” has been identified as a key nitrite-oxidizing bacterium (NOB) performing the second step of nitrification, nitrite oxidation to nitrate, in wastewater treatment plants (WWTPs).
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Low Temperature and Neutral pH Define Candidatus Nitrotoga sp. as a Competitive Nitrite Oxidizer in Co-Culture with Nitrospira defluvii

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By Simone Wegen, Boris Nowka, Eva Spieck
| asm.org
Environmental Microbiology Simone Wegen, Boris Nowka, Eva Spieck DOI: 10.1128/AEM.02569-18 ABSTRACT Nitrification is an essential process for N-removal in activated sludge to avoid toxicity of ammonium and nitrite. Besides Nitrospira, Candidatus Nitrotoga has been identified as a key nitrite-oxidizing bacterium (NOB) performing the second step of nitrification - nitrite oxidation to nitrate - in wastewater treatment plants (WWTPs).
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