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Articles by Skyler L. Jackman
Fast resupply of synaptic vesicles requires synaptotagmin-3 - Nature
Abstract Sustained neuronal activity demands a rapid resupply of synaptic vesicles to maintain reliable synaptic transmission. Such vesicle replenishment is accelerated by submicromolar presynaptic Ca2+ signals by an as-yet unidentified high-affinity Ca2+ sensor1,2. Here we identify synaptotagmin-3 (SYT3)3,4 as that presynaptic high-affinity Ca2+ sensor, which drives vesicle replenishment and short-term synaptic plasticity.
In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films
Neuroscience Fill out the form below to receive a free trial or learn more about access: Enter your email below to get your free 10 minute trial to JoVE! We use/store this info to ensure you have proper access and that your account is secure. We may use this info to send you notifications about your account, your institutional access, and/or other related products. To learn more about our GDPR policies click here. If you want more info regarding data storage, please contact gdpr@jove.com.
Silk Fibroin Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins
Silk/AAV-Coated Optical Fibers Can Be Used to Reliably Trigger Specific Behaviors For many optogenetic applications, a viral vector that expresses a light-activated opsin is injected into a target region, and then an optical fiber is implanted into that region for activation or inhibition of transduced neurons (Figure 1Figure 1A). This approach has several limitations. First, this procedure involves physically perturbing the brain twice.
Synaptotagmin 7 confers frequency invariance onto specialized depressing synapses
At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations1,2. However, some auditory, vestibular and cerebellar synapses maintain constant strength over a wide range of firing frequencies3,4,5, and as a result efficiently encode firing rates.
The Mechanisms and Functions of Synaptic Facilitation
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. ReviewThe Mechanisms and Functions of Synaptic Facilitation© 2017 Elsevier Inc.
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