So Yoen Choi

Keywords alphavirus arbovirus receptor viral glycoprotein emerging virus encephalitis Introduction Several alphaviruses cause encephalitis outbreaks in humans and equids with unpredictable frequency and scale, including western equine encephalitis virus (Alphavirus western, WEEV), eastern equine encephalitis virus (EEEV), and Venezuelan equine encephalitis virus (VEEV).1,2,3 WEEV infection results in mild, asymptomatic illness or encephalitis, which can leave survivors with neurological...

Empathic function is essential for the well-being of social species. Empathy loss is associated with various brain disorders and represents arguably the most distressing feature of frontotemporal dementia (FTD), a leading form of presenile dementia. The neural mechanisms are unknown.

Abstract The GGGGCC repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, it is not known which dysregulated molecular pathways are primarily responsible for disease initiation or progression. We established an inducible mouse model of poly(GR) toxicity in which (GR)80 gradually accumulates in cortical excitatory neurons.