Sofia Töyrä Silfverswärd on Muck Rack

Sofia Töyrä Silfverswärd

As seen in: Nature
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Articles

Insulin enables acquisition of the IL7R + memory phenotype in PD1 + T cells in RA tissues

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By Venkataragavan Chandrasekaran, Malin C Erlandsson, David Svensson, Eric Malmhall-Bah, Sofia Töyrä Silfverswärd, Rille Pullerits, Gergely Katona, Maria Bokarewa
| Nature Verified
Abstract Insulin signaling regulates cellular metabolism in an epigenetic manner, but its role in the immune cell homeostasis remains unknown. High plasma insulin obstructs efficient insulin signaling and rewires metabolic activity in autoimmunity. In this study, we explored the functional consequences of insulin signaling for the metabolism and phenotype of effector CD4+ T cells in blood and synovial tissue of patients with rheumatoid arthritis (RA).
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Insulin Predicts Methotrexate Response by Affecting Transcription of Methotrexate Target Genes in the Treatment-Naive Rheumatoid Arthritis

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By Malin C Erlandsson, Venkataragavan Chandrasekaran, Victoria ME Lundgren, Sofia Töyrä Silfverswärd
| preprints.org
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