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Articles by Soham Chanda
[2401.13024] Augmentation varieties and disk potentials III
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[2401.13021] Augmentation varieties and disk potentials II
arXiv:2401.13021 (math) Download PDF Comments: Subjects: Symplectic Geometry (math.SG) MSC classes: 53D40 Cite as: arXiv:2401.13021 [math.SG] (or arXiv:2401.13021v1 [math.SG] for this version) https://doi.org/10.48550/arXiv.2401.13021 Submission history From: Chris T.
[2310.17821] Augmentation varieties and disk potentials I
arXiv:2310.17821 (math) [Submitted on 26 Oct 2023 (v1), last revised 23 Jan 2024 (this version, v2)] Download PDF HTML (experimental) Comments: Subjects: Symplectic Geometry (math.SG) MSC classes: 53D05, 53D10, 57R17, 53D42 Cite as: arXiv:2310.17821 [math.SG] (or arXiv:2310.17821v2 [math.SG] for this version) https://doi.org/10.48550/arXiv.2310.17821 Submission history From: Chris T.
Induction of synapse formation by de novo neurotransmitter synthesis - Nature Communications
Abstract A vital question in neuroscience is how neurons align their postsynaptic structures with presynaptic release sites. Although synaptic adhesion proteins are known to contribute in this process, the role of neurotransmitters remains unclear. Here we inquire whether de novo biosynthesis and vesicular release of a noncanonical transmitter can facilitate the assembly of its corresponding postsynapses.
Efficient generation of dopaminergic induced neuronal cells with midbrain characteristics
Highlights • Ascl1 alone can induce tyrosine hydroxylase (TH)-positive ES-iN cells • Ascl1 alone, or with Nurr1 and Lmx1a, induce peripheral TH-positive cells • WNT1 and neurotrophic factors increase TH-positive iN cells in culture • A 6-factor combination induces TH-positive dopamine iN cells of central identity Summary The differentiation of pluripotent stem cells can be accomplished by sequential activation of signaling pathways or through transcription factor programming.
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons
Highlights • In human brain, the synaptic protein NLGN4 is primarily expressed in cerebral cortex • Unlike in mouse, human NLGN4 protein preferentially localizes to glutamatergic synapses • NLGN4 gain of function induces an excitatory synaptic phenotype in human neurons • R704C increases excitatory synapse density, synapse transmission, and AMPAR affinity Summary The autism-associated synaptic-adhesion gene Neuroligin-4 ( NLGN4) is poorly conserved evolutionarily, limiting conclusions from...
Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity
Highlights • Reprogrammed human neurons progress through distinct developmental stages • VPA treatment impairs the morphology and functional maturation of developing neurons • VPA exposure alters neuronal properties by inhibiting HDAC and GSK-3 pathways • The cytoskeletal protein MARCKSL1 mediates VPA-induced morphological defects Summary Human pluripotent stem cells can be rapidly converted into functional neurons by ectopic expression of proneural transcription factors.
Transdifferentiation of human adult peripheral blood T cells into neurons
To curb the spread of misinformation in science and medicine, the scientific community should devote more resources to technological approaches that identify false and retracted findings.
Transdifferentiation of human adult peripheral blood T cells into neurons
Recent advances in genomics have revealed that many polygenetic diseases are caused by complex combinations of many common variants with individually small effects. Thus, building informative disease models requires the interrogation of many patient-derived genetic backgrounds in a disease-relevant cell type. Current approaches to obtaining human neurons are not easy to scale to many patients.
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