KEYWORDS: Overactive bladder polypharmacy anticholinergic burden cognitive decline dementia antimuscarinic 1. Introduction Anticholinergic medications, also known as antimuscarinic agents, are a mainstay of pharmacological management in urology, in the treatment of overactive bladder (OAB) [Citation1]. OAB is defined by symptoms of urgency, with or without urgency, incontinence, increased urinary frequency, and nocturia, and its prevalence rises with advancing age [Citation2].