Song Ih Ahn

Introduction Alzheimer’s disease (AD) constitutes the most common neurodegenerative disorder, affecting around 24 million people worldwide. In addition to the key neuropathological hallmarks of AD including amyloid plaques, neurofibrillary tangles, glial activation, and neuronal loss, early blood-brain barrier (BBB) breakdown and vascular dysregulation have been reported in vivo (Serrano-Pozo et al., 2011; Zenaro et al., 2017).

Article info Publication history Accepted: March 23, 2023 Received: June 25, 2022 Publication stage In Press, Accepted Manuscript Footnotes Statement of Significance Cellular morphology and motility are important factors that encompass the alterations in protein and gene-level expressions within cells. In pathological conditions, microglia, the resident brain immune cells, are known to undergo morphodynamic transformations in response to various physicochemical stimuli.