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Soon Il Higashino on Muck Rack

Soon Il Higashino

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Multiomics and deep learning dissect regulatory syntax in human development

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By Betty Liu, Selin Jessa, Samuel Kim, Yan Ting Ng, Georgi K. Marinov, Derek Chen, Benjamin Parks, Tri C. Nguyen, Trí Nguyễn, Austin Wang, Sean Wang, Serena Tan, Michael Kosicki, Len A. Pennacchio, Eyal Ben-David, Anca M. Pasca, Anshul Kundaje, William J. Greenleaf, Soon Il Higashino, Kyle K. H. Farh
| Nature Verified
Abstract Transcription factors establish cell identity during development by binding regulatory DNA in a sequence-specific manner, often promoting local chromatin accessibility and regulating gene expression1. Mapping accessible chromatin offers critical insights into transcriptional control, but available datasets for human development are restricted to bulk tissue, single organs or single modalities2.
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