JAN 07, 2026 AAO 2025 Video Program Cataract/Anterior Segment This video describes the trifold technique, which can be used to manage large iris defects. Ocular trauma, iatrogenic iris damage, and, rarely, iris colobomas can lead to large, nonappositional iris defects. In such scenarios, closing the iris from the root to the pupillary margin is challenging due to abnormal directional vectors.