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Sophie Barral on Muck Rack

Sophie Barral

As seen in: BioRxiv, Cell Press, eLife
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Articles

ATAD2 mediates chromatin-bound histone chaperone turnover

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By Ariadni Liakopoulou, Daniel Perazza, Sophie Barral, Emeline Lambert
| eLife
eLife Assessment This valuable study explores the role of the chromatin regulator ATAD2 in mouse spermatogenesis. The data convincingly demonstrate that ATAD2 is essential for proper chromatin remodeling in haploid spermatids, influencing gene accessibility, H3.3-mediated transcription, and histone eviction.
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ATAD2 drives HIRA/histone H3.3-dependent chromatin dynamics

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By Sophie Barral, Ariadni Liakopoulou, Fayçal Boussouar, Daniel Perazza
| BioRxiv
Abstract ATAD2, expressed predominantly in embryonic stem cells as well as in spermatogenic cells emerges as a pivotal regulator of chromatin dynamics by mediating chromatin-bound histone chaperone turnover. Here, investigating the role of ATAD2 in spermatogenesis, we show that through its preponderant expression in haploid male germ cells, ATAD2 modulates the HIRA-dependent H3.3 genome localization and H3.3-dependent gene transcriptional regulation.
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Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells

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By Sophie Barral, Hitoshi Shiota, Thierry Buchou
| Cell Press Verified
Nuclear protein in testis (Nut) is a universal oncogenic driver in the highly aggressive NUT midline carcinoma, whose physiological function in male germ cells has been unclear. Here we show that expression of Nut is normally restricted to post-meiotic spermatogenic cells, where its presence triggers p300-dependent genome-wide histone H4 hyperacetylation, which is essential for the completion of histone-to-protamine exchange.
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