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Soumen Barman

As seen in: Royal Society of Chemistry, BioRxiv
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Articles

Olive phenolic compounds, potent tankyrase 1 inhibitor exhibit anti colon cancer effects by blocking Wnt/β-catenin pathway

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By Soumen Barman, Arindam Sain, Dipsikha Khamrai, Meduri Srinivas
| BioRxiv
Abstract Colon cancer (CC) needs special attention to develop novel targets and therapeutic approaches, as the total number of morbidity and mortality is growing rapidly. Although Olive has been long reported for its anti-CC activities but the mode is not completely understood yet. Here, we targeted tankysare 1 (TNKS), an important mediator of the Wnt/β-catenin pathway, crucial in colon carcinogenesis.
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Insulin Fibril Inhibition Using Glycopolymeric Nanoassemblies

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By Pooja Ghosh, Soumen Barman, Avisek Bera, Sagnik Bhattacharya
| Royal Society of Chemistry Verified
Insulin Fibril Inhibition Using Glycopolymeric Nanoassemblies Avisek Bera, Pooja Ghosh, Soumen Barman, Sagnik Bhattacharya, Babu Sudhamalla, Kalyan Goswami and Priyadarsi De Abstract To address the obstacle in insulin protein homeostasis leading to the formation of neurotoxic amyloid plaques associated with different diseases, herein we synthesized block copolymers using the reversible addition-fragmentation chain transfer (RAFT) polymerization method, composed of tert-butoxycarbonyl (Boc)...
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Identification of novel natural product inhibitors of BRD4 using high throughput virtual screening and MD simulation

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By Soumen Barman, Snehasudha Subhadarsini Sahoo, Jyotirmayee Padhan, Babu Sudhamalla
| BioRxiv
New Results doi: https://doi.org/10.1101/2022.11.25.517921 Abstract Bromodomains are evolutionarily conserved structural motifs that recognize acetylated lysine residues on histone tails. They play a crucial role in shaping chromatin architecture and regulating gene expression in various biological processes. Mutations in bromodomains containing proteins leads to multiple human diseases, which makes them attractive target for therapeutic intervention.
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