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Articles

Peripheral γδ T-cell remodeling in psoriasis is associated with effector-biased transcriptional organization and reduced representation of a circulating CSMD1 -marked state

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By Guangdong Pharmaceutical, South Normal
| Frontiers in Immunology
Abstract Background: Despite the prominent immune dysregulation in psoriasis, the organization of peripheral blood γδ T cell states remains incompletely defined. Methods: Here, we performed single-cell transcriptomic profiling of enriched peripheral blood-derived γδ T cells from healthy donors and patients with psoriasis.
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Monocyte TLR2/4 as predictive biomarkers for progression from dengue warning signs to severe disease

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By South Normal
| Frontiers in Immunology
Abstract Background: The World Health Organization (WHO) classification system, comprising dengue fever (DF), dengue with warning signs (DWS), and severe dengue (SD), has been widely adopted globally; however, clinical management remains challenging. Current warning sign criteria lack specificity, frequently failing to distinguish patients progressing to severe disease from those with transient illness, thereby contributing to delayed interventions and missed therapeutic windows.
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Brain imaging-derived phenotypes influence risk of bipolar disorder: comprehensive exposome-wide association and wide-angled genetic analyses

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By Sun Yat-sen, South Normal, Biomedical Informatics
| TechTrends
Background Despite many reported imaging markers for bipolar disorder (BD), systematic assessment across diverse brain imaging-derived phenotypes (IDPs) is lacking. We used epidemiological and genetic analyses to progress from association to causality and identify candidate biomarkers and potential pathways of BD. Methods We conducted an Exposome-Wide Association Study (ExWAS) in 35,680 UK Biobank participants to assess associations of 686 brain IDPs with BD.
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