Srinivasagan Ramkumar on Muck Rack

Srinivasagan Ramkumar

As seen in: The Journal of Biological Chemistry
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Articles

Unraveling the Mystery of Ocular Retinoid Turnover: Insights from Albino Mice and the Role of STRA6

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By Beata Jastrzebska, Diego Montenegro, Janet R. Sparrow, Srinivasagan Ramkumar
| The Journal of Biological Chemistry Verified
Abstract A delicate balance between photon absorption for vision and protection of photoreceptors from light damage is pivotal for ocular health. This equilibrium is governed by the light-absorbing 11-cis-retinylidene chromophore of visual pigments, which, upon bleaching, transforms into all-trans-retinal and undergoes regeneration through an enzymatic pathway, named the visual cycle.
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