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Sromona Das

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Articles

Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodies

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By Marc Carceles-Cordon, Eliza Brody, Masen L. Boucher, Michael Gallagher Verified, Robert T. Skrinak, Travis Unger, Cooper Penner, Adama Berndt, Sromona Das, Katie Lam, Rudolf Jaenisch, Vivianna Van Deerlin, Edward Lee, Kurt R. Brunden, Kelvin C. Luk, Alice S. Chen-Plotkin
| Cell Press Verified
Keywords GPNMB Parkinson’s disease alpha-synuclein aSyn microglia neuroinflammation anti-GPNMB antibody Introduction Parkinson’s disease (PD), the second most common neurodegenerative disorder worldwide,1,2 remains incurable in part due to a lack of understanding regarding the molecular events that orchestrate alpha-synuclein (aSyn) spread throughout the brain.3 In 2022, we reported that GPNMB, encoding glycoprotein nonmetastatic melanoma B (GPNMB), is the target gene of a chromosome 7 PD...
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