Stane Pajk

Introduction Click to copy section linkSection link copied! Stimulation of the innate immune system is essential for effective vaccinations and immunotherapies.

Synthesis of Compounds tert-Butyl (2-(2-(4-((6-Amino-2-butoxy-8-hydroxy-9H-purin-9-yl)methyl)benzamido)ethoxy)ethyl)carbamate (1) tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate (380 mg, 1.86 mmol) and DIPEA (0.523 mL, 2.99 mmol) were dissolved in DCM (0.5 mL) and added to the stirring solution of compound T7 (200 mg, 0.56 mmol) in DMSO (3 mL). To an ice-chilled solution was added COMU (0.640 g, 1.49 mmol), and the mixture was stirred at room temperature for 3 h.

1. Introduction Click to copy section linkSection link copied! Antimicrobial resistance (AMR) is one of the biggest global public health challenges. Infections are on the rise and are becoming increasingly difficult to treat with current therapies. (1,2) Drug-resistant bacteria are associated with approximately 4.7 million deaths per year, a number that is expected to rise to 8.2 million by 2050.