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Stefan Barthels on Muck Rack

Stefan Barthels

As seen in: The Journal of Biological Chemistry
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Articles

The radical SAM protein HemW is a heme chaperone

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By Vera Haskamp, Simone Karrie, Toni Mingers, Stefan Barthels
| The Journal of Biological Chemistry Verified
Radical S-adenosylmethionine (SAM) enzymes exist in organisms from all kingdoms of life, and all of these proteins generate an adenosyl radical via the homolytic cleavage of the S–C(5?) bond of SAM. Of particular interest are radical SAM enzymes, such as heme chaperones, that insert heme into respiratory enzymes. For example, heme chaperones insert heme into target proteins but have been studied only for the formation of cytochrome c-type hemoproteins.
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The radical SAM Protein HemW is a Heme Chaperone

|
By Vera Haskamp, Simone Karrie, Toni Mingers, Stefan Barthels
| The Journal of Biological Chemistry Verified
Radical S-adenosylmethionine (SAM) enzymes exist in organisms from all kingdoms of life, and all of these proteins generate an adenosyl radical via the homolytic cleavage of the S–C(5’) bond of SAM. Of particular interest are radical SAM enzymes, such as heme chaperones, that insert heme into respiratory enzymes. For example, heme chaperones insert heme into target proteins, but have been studied only for the formation of cytochrome c type hemoproteins.
Open in Who Shared Issue with article?
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