Stefania Barruscotti

Submitted: 18 February 2025 You are already at the latest version Melanoma brain metastases (MBM) remain a major therapeutic challenge, requiring a multidisciplinary approach integrating systemic and local therapies. The advent of immune checkpoint inhibitors and targeted therapies has markedly improved patients’ survival, with the combination of ipilimumab and nivolumab now considered as first-line systemic treatment for patients with asymptomatic MBM.

Open AccessArticle by Carlo Francesco Tomasini 1,2,*,†, Andrea Michelerio 1,†, Eugenio Isoletta 1, Stefania Barruscotti 2, Barbara Wade 3 and Alba Muzzi 4 1 Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy 2 Dermatology Clinic, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy 3 Department of Science of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy 4 Department of Quality and Risk Management,...

Abstract Pigmented mammary Paget's disease is a very rare variant of mammary Paget's disease linked to an underlying carcinoma in almost all cases. We present the case of a 62-year-old female patient who came to our attention for the evaluation of a monolateral asymptomatic pigmented lesion of the right nipple, which turned out to be a pigmented mammary Paget's disease unassociated to an underlying malignancy – an extremely rare entity only anecdotally reported in literature.