Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Stephan Windecker
Long-Term Perspective on the Landscape of Recognized and Unrecognized Myocardial Infarction
Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide.1 At the level of an individual patient, MI manifests as a life-threatening medical emergency; at the population level it constitutes an enduring public health challenge.
Machine Learning–Driven Risk Prediction Model in Transthyretin Amyloid Cardiomyopathy
|
Machine Learning–Driven Risk Prediction Model in Transthyretin Amyloid Cardiomyopathy Supplement 1. eAppendix. Secondary Analyses: Treated Subgroup, Individual Endpoints, and Cox-LASSO Comparison eFigure 1. Flowchart of the Study eFigure 2. Kaplan-Meier Event-Free Survival Curves Stratified by Center eFigure 3. Decision Curve Analysis Across Centers at 2 and 3 Years eFigure 4. Global Explainability of the RSF Models for Each Fold eFigure 5. Local Interpretability Plot for Selected Cases eFigure 6.
By Giovanni Baj, Nicola Ciocca, Pooya Mohammadi Kazaj, Xuan Ma, Simon F. Stämpfli, Niklas F. Ehl, Sarah Hugelshofer, Otmar Pfister, Joëlle Lehmann, Christoph P. Ryffel, Lukas Hunziker, Michael Poledniczek, Andreas Kammerlander, George C. M. Siontis, Stephan Windecker, Moritz Hundertmark, Christian Nitsche Verified, Isaac Shiri, Christoph Gräni, Annina A. Studer Bruengger
|
JAMA Cardiology
Dual Antiplatelet Therapy Duration in Patients at High Bleeding Risk : A Systematic Review and Meta-Analysis
|
Dual Antiplatelet Therapy Duration in Patients at High Bleeding Risk: A Systematic Review and Meta-Analysis Key Points Question Among patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention (PCI), is an abbreviated dual antiplatelet therapy (DAPT) regimen safer and as effective as standard DAPT duration?
By Andrea Zito, Antonio Landi, Deepak L. Bhatt, Shao-Liang Chen, Giuseppe De Luca, Anna Franzone, Hyeon-Cheol Gwon, Jeehoon Kang, Joo-Yong Hahn, Sung-Jin Hong, Yangsoo Jang, Byeong-Keuk Kim, Hyo-Soo Kim, Takeshi Kimura, Roxana Mehran, Philippe Gabriel Steg, Gregg W. Stone, Pascal Vranckx, Stephan Windecker, Marco Valgimigli, Kyoung-Woo Park
|
JAMA Cardiology
Transforming the Care of Female and Low-Risk Younger Patients With Aortic Stenosis Through Guidelines
More from this programme Part 1 Prof Vijay Kunadian explores advances in aortic stenosis care, focusing on female and low-risk patients. She outlines sex-related differences in presentation, the need for evidence to inform sex-specific recommendations and the importance of addressing underdiagnosis in women. She also highlights new guidelines lowering the TAVI age threshold from 75 to 70 years, expanding access for lower-risk patients and raising key clinical and economic implications.
Relationship Between Postprocedural Transvalvular Pressure Gradient and Hemodynamic Valve Deterioration After Transcatheter Aortic Valve Replacement
Hemodynamic valve deterioration (HVD) following transcatheter aortic valve replacement (TAVR) is a significant concern in lifetime management, as it increases the risk of mortality, heart failure, and aortic valve reintervention( 1 2 ). However, the risk factors and mechanisms contributing to HVD remain incompletely understood. The Valve Academic Research Consortium (VARC)-3 definition of HVD is based on temporal changes in echocardiographic hemodynamic parameters( 3 ).
Aortic Valve Replacement in Women: A Pooled Analysis of the RHEIA and PARTNER 3 Trials
References 1. "Excess mortality and undertreatment of women with severe aortic stenosis". J Am Heart Assoc . 2021;10:1: e018816. 2. "Sex disparities in patients with symptomatic severe aortic stenosis". Am Heart J . 2021;237:116-126. 3. "Impact of sex on the management and outcome of aortic stenosis patients". Eur Heart J . 2021;42:27: 2683-2691. 4. "Underrepresentation of women in cardiovascular trials- it is time to shatter this glass ceiling". Am Heart J Plus . 2022;13:100109. 5.
Volume 46 Issue 18
Oxford University Press uses cookies to enhance your experience on our website. By selecting ‘accept all’ you are agreeing to our use of cookies. You can change your cookie settings at any time. More information can be found in our Cookie Policy.
Clinical Outcomes in Patients With Acute Pulmonary Embolism Undergoing Ultrasound‐Assisted Catheter‐Directed Thrombolysis
Research Article Open Access Nonstandard Abbreviations and Acronyms rt‐PA recombinant tissue‐type plasminogen activator USAT ultrasound‐assisted catheter‐directed thrombolysis Clinical Perspective • Ultrasound‐assisted catheter‐directed thrombolysis (USAT) effectively reduces right ventricular overload in patients with intermediate‐high and high‐risk acute pulmonary embolism. • USAT is associated with low rates of periprocedural bleeding, death, or other pulmonary embolism‐related complications.
Volume 46 Issue 16
This PDF is available to Subscribers Only For full access to this pdf, sign in to an existing account, or purchase an annual subscription.
Conduction Disturbances After Transcatheter Aortic Valve Replacement: An Update on Epidemiology, Preventive Strategies, and Management
References 1. "2020 ACC/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines". Circulation . 2021;143:5: e35-e71. https://doi.org/10.1161/CIR.0000000000000932. 2. "Impact of new pacemaker implantation following surgical and transcatheter aortic valve replacement on 1-year outcome". Eur J Cardiothorac Surg . 2020;57:1: 151-159.
Renin-Angiotensin System Inhibition and Cardiac Damage in Patients Undergoing Transcatheter Aortic Valve Replacement
Abstract The optimal medical treatment strategy after transcatheter aortic valve replacement (TAVR) has not been established, and may be impacted by the extent of extra-valvular cardiac damage. We aimed to investigate the prognostic effect of renin-angiotensin system (RAS) inhibitors in TAVR patients stratified by the extent of extra-valvular cardiac damage.
Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients: 5-Year Outcomes of the SURTAVI Randomized Clinical Trial
IMPORTANCE: In patients with severe aortic valve stenosis at intermediate surgical risk, transcatheter aortic valve replacement (TAVR) with a self-expanding supra-annular valve was noninferior to surgery for all-cause mortality or disabling stroke at 2 years. Comparisons of longer-term clinical and hemodynamic outcomes in these patients are limited.
Relationship between Upstream Cardiac Damage and Myocardial Injury in Patients with Aortic Stenosis undergoing Transcatheter Aortic Valve Implantation
The cardiac damage staging classification proposed by Généreux and colleagues categorizes extra-valvular damage due to aortic stenosis (AS) into left ventricular damage, left atrial and mitral valve damage, pulmonary artery and tricuspid valve damage, and right ventricular damage, and has been demonstrated to stratify prognosis following aortic valve replacement 1 Généreux P. Pibarot P. Redfors B. et al. Staging classification of aortic stenosis based on the extent of cardiac damage. Eur Heart J.
Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Patient-Level Meta-Analysis | Clinical Pharmacy and Pharmacology | JAMA Cardiology | JAMA Network
Key Points Question Are ticagrelor or clopidogrel monotherapy after percutaneous coronary intervention (PCI) and 1 to 3 month dual antiplatelet therapy (DAPT) similarly effective and safer compared with standard DAPT? Findings This systematic review and individual patient data meta-analysis including 6 randomized clinical trials with 25 960 patients found that ticagrelor monotherapy was noninferior to DAPT for death, myocardial infarction, or stroke and superior for major bleeding.
Geographical variations in the effectiveness and safety of abbreviated or standard antiplatelet therapy after PCI in patients at high bleeding risk
These cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work. These cookies do not store any personally identifiable information.
Safety and Efficacy of Balloon-Expandable Transcatheter Aortic Valve Implantation in Patients with Extreme Horizontal Aorta
These cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work. These cookies do not store any personally identifiable information.
Mitral TEER With Fourth-Generation Devices: A New Era of Possibilities?
Save citation to file Format: Add to My Bibliography Your saved search Name of saved search: Search terms: Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Create a file for external citation management software
Sex Differences in Safety and Effectiveness of LAAO: Insights From the Amulet IDE Trial
JACC Journals › JACC: Interventions › Archives › Vol. 15 No. 21 Abstract Background Women have higher rates of acute complications after left atrial appendage occlusion (LAAO). However, data on long-term safety and effectiveness are limited. Objectives The aim of this study was to examine sex-specific short- and long-term outcomes after LAAO in the Amulet IDE (Amplatzer™ Amulet™ LAA Occluder) trial.
Cardiovascular Meta-analyses: Fool's Gold or Gold for Fools?
close Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit.
Surgery or TAVI?
Abstract and Introduction Abstract Graphical Abstract: Decision-making process between TAVI and SAVR. Refer to Figures 2, 4, and 6 for details of the valve morphology category. Refer to Figure 3 for details on the femoral access category. Refer to Figure 7 for more details on concomitant valve disease. Refer to Figure 8 for more details on coronary artery disease.
Polymer-Based Versus Polymer-Free Stents in High Bleeding Risk Patients: Final 2-Year Results From Onyx ONE
JACC Journals › JACC: Interventions › Archives › Vol. 15 No. 11 Abstract Background Resolute Onyx polymer-based zotarolimus-eluting stents (ZES) were noninferior in safety and effectiveness to BioFreedom polymer-free biolimus A9-coated stents (DCS) in high-bleeding-risk (HBR) patients treated with 1-month dual antiplatelet therapy (DAPT) followed by single antiplatelet therapy (SAPT) at 1 year. Objectives This study reports the final 2-year results of the randomized Onyx ONE trial.
Sudden Cardiac Death in Ischemic Heart Disease
JACC: Cardiovascular Imaging State-of-the-Art Review Christoph Gräni, Dominik C. Benz, Sumit Gupta, Stephan Windecker and Raymond Y. Kwong This article requires a subscription or purchase to view the full text. If you are a subscriber or member, click the login link or the subscribe link in the top menu above to access this article. Author + information vol. 13 no.
Antithrombotic therapies, troponin protocols among changes to ESC NSTEACS guideline
August 31, 2020 2 min read Save Perspective from Source/Disclosures Source: Thiele H, et al. 2020 ESC guidelines on non ST-segment elevation acute coronary syndromes. Presented at: European Society of Cardiology Congress; Aug. 29-Sept. 1, 2020 (virtual meeting).
Trimetazidine does not improve angina, other outcomes after PCI
August 30, 2020 2 min read Save Source/Disclosures Source: Ferrari R, et al. Hot Line: ATPCI. Presented at: European Society of Cardiology Congress; Aug. 29-Sept. 1, 2020 (virtual meeting). Disclosures: The study was funded by Servier. Ferrari reports he has financial ties with Art Research and Science, Boehringer Ingelheim, Doc Generici, Lupin, Merck Serono, Pfizer, Servier, Spa Prodotti Antibiotici and Sunpharma.
Predilatation and paravalvular leakage risk in TAVR - Authors' reply
We thank Liang Yao and colleagues for their interest in our Article. 1 Lanz J Kim WK Walther T et al. Safety and efficacy of a self-expanding versus a balloon-expandable bioprosthesis for transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis: a randomised non-inferiority trial. Lancet.
Impact of the COVID-19 pandemic on interventional cardiology practice: results of the EAPCI survey
Marco Roffi1, MD; Davide Capodanno2, MD, PhD; Stephan Windecker3, MD; Andreas Baumbach4,5, MD, PhD; Dariusz Dudek6,7, MD, PhD 1. Division of Cardiology, University Hospitals, Geneva, Switzerland; 2. Division of Cardiology, CAST, P.O. “G. Rodolico”, Azienda Ospedaliero-Universitaria “Policlinico-Vittorio Emanuele”, University of Catania, Catania, Italy; 3. Department of Cardiology, Swiss Cardiovascular Center, University Hospital Bern, Bern, Switzerland; 4.
Polymer-based or Polymer-free Stents in Patients at High Bleeding Risk
19 References 33 Citing Articles Related Articles Abstract Background Polymer-free drug-coated stents provide superior clinical outcomes to bare-metal stents in patients at high bleeding risk who undergo percutaneous coronary intervention (PCI) and are treated with 1 month of dual antiplatelet therapy. Data on the use of polymer-based drug-eluting stents, as compared with polymer-free drug-coated stents, in such patients are limited.
Two‐year outcomes of the MITRA‐FR trial: towards an integrated approach in the evaluation of patients with secondary mitral regurgitation
This article refers to ‘Percutaneous repair or medical treatment for secondary mitral regurgitation: outcomes at 2 years’ by B. Iung et al., published in this issue on pages xxx.
A Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement
Abstract Background Whether the direct factor Xa inhibitor rivaroxaban can prevent thromboembolic events after transcatheter aortic-valve replacement (TAVR) is unclear.
Evolocumab for Early Reduction of LDL Cholesterol Levels in Patients With Acute Coronary Syndromes (EVOPACS)
Journal of the American College of Cardiology Original Investigation Konstantinos C. Koskinas, Stephan Windecker, Giovanni Pedrazzini, Christian Mueller, Stéphane Cook, Christian M. Matter, Olivier Muller, Jonas Häner, Baris Gencer, Carmela Crljenica, Poorya Amini, Olga Deckarm, Juan F. Iglesias, Lorenz Räber, Dik Heg and François Mach This article requires a subscription or purchase to view the full text.
Antithrombotic Therapy in Patients With Atrial Fibrillation and Acute Coronary Syndrome Treated Medically or With Percutaneous Coronary Intervention or Undergoing Elective Percutaneous Coronary Intervention | Circulation
Clinical Perspective What Is New? We assessed different antithrombotic strategies in patients with atrial fibrillation with acute coronary syndromes (ACS) managed medically, in patients with ACS undergoing percutaneous coronary intervention (PCI), and in patients undergoing elective PCI. It is the only trial in the field that included patients with ACS managed medically.
Prevention, Diagnosis, and Management of Radiation-Associated Cardiac Disease
Journal of the American College of Cardiology The Present and Future - JACC Scientific Expert Panel Milind Y. Desai, Stephan Windecker, Patrizio Lancellotti, Jeroen J. Bax, Brian P. Griffin, Oren Cahlon and Douglas R. Johnston This article requires a subscription or purchase to view the full text. If you are a subscriber or member, click the login link or the subscribe link in the top menu above to access this article. Author + information Milind Y.
Diagnosis and Management of Anomalous Coronary Arteries with a Malignant Course
Login or register to view PDF. Abstract Although the prevalence of anomalous coronary artery from the opposite sinus (ACAOS) in the general population is low, more frequent use of invasive and non-invasive imaging to rule out coronary artery disease has seen an increase in absolute numbers of ACAOS. ACAOS are traditionally classified as malignant (with an interarterial course) and benign variants.
Biodegradable-polymer stents versus durable-polymer stents - Authors' reply
The BIOSCIENCE trial 1 Pilgrim T Heg D Roffi M et al. Ultrathin strut biodegradable polymer sirolimus-eluting stent versus durable polymer everolimus-eluting stent for percutaneous coronary revascularisation (BIOSCIENCE): a randomised, single-blind, noninferiority trial. Lancet. 2014; 384: 2111-2122 was powered to assess non-inferiority for the primary outcome of target lesion failure at 12 months.
Cardiac Interventions Today - TAVR Durability: What We Know and When Will We Know What We Donât?
A discussion of what defines durability, an overview of the surgical and transcatheter experience to date, and future directions. By Faisal Khan, MBBS; and Stephan Windecker, MD Patients with severe aortic valve stenosis present with breathlessness, angina, and syncope and, if left untreated, are at an increased risk of death.
1-Year Outcomes of the CENTERA-EU Trial Assessing a Novel Self-Expanding Transcatheter Heart Valve
Didier Tchétché, MDa,∗ (d.tchetche{at}clinique-pasteur.com), Stephan Windecker, MDb, A. Markus Kasel, MDc, Ulrich Schaefer, MDd, Stephen Worthley, MDe, Axel Linke, MDf, Mohamed Abdel-Wahab, MDg, Herve Le Breton, MDh,i,j, Lars Søndergaard, MD, MSck, Mark S.
Interpretation of results of pooled analysis of individual patient data
1 Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data. : of individual patient data from randomised trials comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) in patients with multivessel or left main disease.
From bare metal to barely anything: an update on coronary stenting
In 2017, percutaneous coronary intervention (PCI) enters its 40th anniversary since the first description of balloon coronary angioplasty in a human by Andreas Gruntzig in 1977.1 Since then, the safety and efficacy of the procedure has steadily improved with continuous advances in the technique, equipment and procedural success.
From bare metal to barely anything: an update on coronary stenting
In 2017, percutaneous coronary intervention (PCI) enters its 40th anniversary since the first description of balloon coronary angioplasty in a human by Andreas Gruntzig in 1977.1 Since then, the safety and efficacy of the procedure has steadily improved with continuous advances in the technique, equipment and procedural success.
Bioresorbable scaffolds: in search of event-free dissolution
2-year outcomes with the Absorb bioresorbable scaffold for treatment of coronary artery disease: a systematic review and meta-analysis of seven randomised trials with an individual patient data substudy
The Conundrum of Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) has matured into the preferred treatment modality for patients with severe aortic stenosis at extreme or high risk for conventional surgery and a valuable alternative for those at intermediate risk in view of similar or superior clinical outcomes and decreased rates of periprocedural adverse events.1–3 In this context, it remains unclear whether other procedure-related events—including atrioventricular conduction disturbances that require...
Concerns about the European Society of Cardiology atrial fibrillation guidelines: reply
We would like to thank you for taking the time to prepare a letter to the Editor of Europace recently, in which you express your thoughts on the matters of conflicts of interest. This letter has been forwarded to the senior leadership of the European Society of Cardiology (ESC), given the guidelines are those of the ESC.
2014 ESC/EACTS Guidelines on myocardial revascularization
The choice, initiation, combination, and duration of antithrombotic strategies for myocardial revascularization depend on the clinical setting [SCAD, NSTE-ACS, STEMI], and the urgency and mode (PCI vs. CABG) of the intervention.
Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous coronary or valve interventions: a joint consensus document of the European Society of Cardiology Working Group on
Introduction Atrial fibrillation (AF) confers a substantial risk of mortality and morbidity from stroke and thrombo-embolism, and this common cardiac arrhythmia represents a major healthcare burden in Europe.1 Stroke prevention is central to the management of AF patients, with the 2012 focused update of the European Society of Cardiology (ESC) guidelines2 recommending oral anticoagulation (OAC) using well-controlled adjusted dose vitamin K antagonists (VKAs, e.g. warfarin) or non-VKA oral...
Short term versus long term dual antiplatelet therapy after implantation of drug eluting stent in patients with or without diabetes: systematic review and meta-analysis of individual participant data from randomised trials | The BMJ
Conclusions Although the presence of diabetes emerged as an independent predictor of MACE after implantation of a drug eluting stent, compared with short term DAPT, long term DAPT did not reduce the risk of MACE but increased the risk of bleeding among patients with stents with and without diabetes. Results Six trials including 11?473 randomised patients were pooled.
Safety and Efficacy of New-Generation Drug-Eluting Stents in Women at High Risk for Atherothrombosis
|
Methods and Results—We pooled patient-level data for women enrolled in 26 randomized trials. Study population was categorized based on the presence or absence of high ATR, which was defined as having history of diabetes mellitus, prior percutaneous or surgical coronary revascularization, or prior myocardial infarction.
By Martin Leon, Philippe Généreux, Patrick W. Serruys, William Wijns, Marco Valgimigli, Ghada W. Mikhail, Usman Baber, Giora Weisz, Takeshi Kimura, Samantha Sartori, Stephan Windecker, Alaide Chieffo, Gennaro Giustino, David Kandzari, George D. Dangas, Gregg W. Stone, Raban Jeger, Giulio G. Stefanini, Olga Salianski, Melissa Aquino, P. Gabriel Steg, Monica O’ Donoghue, Marie-Claude Morice, Edoardo Camenzind, Pieter C. Smits, Clemens Von Birgelen, Jin Y. Cha, Soren Galatius, Dipti Itchhaporia, Laxmi Mehta, Rebecca Ortega, Hyo-Soo Kim, Adnan Kastrati
|
circinterventions.ahajournals.org
Effect of Pulmonary Hypertension Hemodynamic Presentation on Clinical Outcomes in Patients With Severe Symptomatic Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Implantation
Methods and Results—Of 606 consecutive patients undergoing TAVI, 433 (71.4%) patients with severe aortic stenosis and a preprocedural right heart catheterization were assessed. Patients were dichotomized according to whether PH was present (mean pulmonary artery pressure, ≥25 mm Hg; n=325) or not (n=108).
Response to Letter Regarding Article, “Prognostications of Fibrillations”
We thank Dr Sanna et al for their interest in our review.
Procedural Results and Clinical Outcomes of Transcatheter Aortic Valve Implantation in Switzerland
Methods and Results—In a nationwide, prospective, multicenter cohort study (Swiss Transcatheter Aortic Valve Implantation Registry, NCT01368250), outcomes of consecutive transfemoral transcatheter aortic valve implantation patients treated with the Sapien 3 THV (S3) versus the Sapien XT THV (XT) were investigated. An overall of 153 consecutive S3 patients were compared with 445 consecutive XT patients.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Stephan
Contact Stephan, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack