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Steven Leonard

Lawrence
As seen in: Medium, The New York Times, Nature, The Washington Post, The Columbus Dispatch, HistoryNet, ClearanceJobs, Business Leader UK, Wavell Room Audio Reads
Covers:  Leadership, strategy, national defense, military
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Articles by Steven Leonard

Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn’s disease pathogenesis

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By Monika Krzak, Tobi Alegbe, Gareth-Rhys Jones, Mennatallah Ghouraba, Michelle Strickland, Bradley Harris, Reem Satti, Kenneth Arestang, Lucia Ramirez-Navarro, Nilanga Nishad, Marcus Tutert, Matiss Ozols, Guillaume Noell, Steven Leonard, Moritz J. Przybilla, Ciro Ramirez Suastegui, Eleonora Khabirova, Tong Deng, Hanna Najgebauer, Velislava N. Petrova, Carla Jones, Noor Wana, May Xueqi Hu, Jason Skelton, Jasmin Ostermayer, Yong Gu, Wendy Garri, Biljana Brezina, Daniele Corridoni, Miles Parkes, Vivek N. Iyer, Cristina Martin Verified, Rebecca McIntyre, Tim Raine, Carl A. Anderson
| Nature Verified
Abstract Crohn’s disease (CD) is a chronic inflammatory bowel disease exhibiting substantial heterogeneity in clinical presentation and response to therapy. To explore its molecular basis, we developed IBDverse, a large single-cell RNA sequencing (scRNA-seq) dataset of terminal ileal biopsies, profiling over 1.1 million cells from 111 patients with CD and 232 healthy controls.
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Cell-type-resolved genetic variation shapes inflammatory bowel disease risk

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By Tobi Alegbe, Bradley Harris, Laura Fachal, Lucia Ramirez-Navarro, Monika Krzak, Michelle Strickland, Matiss Ozols, Céleste E Cohen, Saniya Khullar, Eleonora Khabirova, Nikolaos Panousis, David Ochoa Verified, Jason Skelton, Jasmin Ostermayer, Yong Gu, Claire Dawson, Tina Thompson, Kenneth Arestang, Nilanga Nishad, Biljana Brezina, Steven Leonard, Vivek N. Iyer, Miles Parkes, Chris Wallace, Rebecca McIntyre, Cristina Martin Verified, Gareth-Rhys Jones, Tim Raine, Carl A. Anderson, Marcus Tutert, Mennatallah Ghouraba, Noor Wana, May Xueqi Hu, Wendy Garri
| Nature Verified
Abstract Most genetic variants associated with complex diseases lie in non-coding regions1, complicating efforts to identify effector genes and relevant cell types. Here we map cis-expression quantitative trait loci (eQTLs) across 2.2 million single cells using intestinal biopsies and blood from 421 individuals, including 125 with inflammatory bowel disease (IBD).
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Power Up: leadership, character, and conflict beyond the superhero multiverse

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By Alice Cumming, Steven Leonard, Jonathan Klug, Kelsey Cipolla
| Business Leader UK Verified
In the edited book Power Up: Leadership, character, and conflict beyond the superhero multiverse, within the pages, there exist chapters crafted to delve into present-day trials concerning leadership, the art of building teams, and managing conflicts, all while underscoring the significance of humaneness and the essence of human behaviour in our reality.
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Kirby’s Rules

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By Steven Leonard
| Medium
Kirby’s Rules Always be: 1. Good to your family Nobody succeeds at this business alone. We all need help. Take time to appreciate everything your family does to support you. They’ll never ask for your thanks, but they darn sure deserve it. 2. Skeptical Don’t be afraid to question policies or programs. You have to be the sanity check. If it doesn’t make sense to you, you are going to have a hard time communicating it. Worse, it may be a bad policy. 3.
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Frederick W. Benteen

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By Steven Leonard
| HistoryNet Verified
Frederick William Benteen can best be described as an enigma. To George Armstrong Custer, Benteen was a nefarious subordinate, a man who doubted every decision, questioned every order. To his own men, the cavalrymen with whom he served, Benteen was a courageous and honorable man, a leader in whom they held the greatest respect and trust.
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