Steven Squires

Abstract Breast cancer is the leading cause of cancer-related death in women worldwide1. Here, in the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770), we assessed whether progesterone receptor antagonism with ulipristal acetate for 12 weeks reduces surrogate markers of breast cancer risk in 24 premenopausal women. We used multilayered OMICs and live-cell approaches as readouts for molecular features alongside clinical imaging and tissue micromechanics correlates.

Introduction Type 1 diabetes is a chronic condition that results from autoimmune destruction of the insulin-secreting pancreatic β cells. The condition affects approximately 9 million people worldwide and is the major global cause of childhood-onset diabetes, although it can occur at any age.1 Insights into the clinical manifestations and underlying pathogenesis of type 1 diabetes have been studied extensively.