Suad A. Alghamdi

Abstract Breast cancer is the leading cause of cancer-related death in women worldwide1. Here, in the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770), we assessed whether progesterone receptor antagonism with ulipristal acetate for 12 weeks reduces surrogate markers of breast cancer risk in 24 premenopausal women. We used multilayered OMICs and live-cell approaches as readouts for molecular features alongside clinical imaging and tissue micromechanics correlates.

Conflicts of Interest The authors declare no conflicts of interest. References 1, , , et al., “Neuroinvasion of Emerging and Re-Emerging Arboviruses: A Scoping Review,” SAGE Open Medicine 12 (2024): 20503121241229847, https://doi.org/10.1177/20503121241229847. 2 and , Arbovirus Encephalitides. StatPearls (StatPearls Publishing Copyright © 2024, StatPearls Publishing LLC., 2024).

Open Access funding provided by the Qatar National Library. No potential conflict of interest was reported by the authors. The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request. Additional information This work was supported by Qatar University grant No. QUPD‐CAS‐23‐24‐491. This study is supported via funding from Prince Sattam bin Abdulaziz University project number (PSAU/2025/R/1446). This was partially funded.