Su-Hyung Park

Abstract Although brain alterations have been reported in post-acute sequelae of SARS-CoV-2 (PASC), their prevalence and relationship to neurodegeneration remain unclear. We analyzed blood proteins and brain MRI from individuals approximately one year after mild COVID-19, categorized as Cog-PASC (with cognitive impairment), Other-PASC (without cognitive impairment), or non-PASC controls, across exploration, covariate-matched, and independent validation cohorts.

Keywords bystander activation IL-15 TCR Ca2+–calcineurin signaling NFATc1 Get full text access Log in, subscribe or purchase for full access. References 1. Kaech, S.M. ∙ Wherry, E.J. ∙ Ahmed, R. Effector and memory T-cell differentiation: implications for vaccine development Nat. Rev. Immunol. 2002; 2:251-262 2. Lee, H. ∙ Jeong, S. ∙ Shin, E.C. Significance of bystander T cell activation in microbial infection Nat. Immunol. 2022; 23:13-22 3. Maurice, N.J. ∙ Taber, A.K. ∙ Prlic, M.

Keywords CD39+CD8+ T cells tumor antigen specificity immunosuppressive activity clear cell renal cell carcinoma anti-PD-1 therapy hypoxia paradoxical prognosis adenosine pathway tumor microenvironment Introduction Hypoxia is a hallmark of solid tumors and plays roles in tumor progression, tumor aggressiveness, and metastatic changes.1,2 Across various types of cancers, tumors with hypoxia typically exhibit a poor prognosis, including resistance to chemotherapy, radiotherapy, and immunotherapy.