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Leveraging Integrated RNA Sequencing to Decipher Adrenomedullin's Protective Mechanisms in Experimental Bronchopulmonary Dysplasia
Keywords Adrenomedullin, Bronchopulmonary Dysplasia, Animals, Mice, Humans, Sequence Analysis, RNA, Disease Models, Animal, Lipopolysaccharides, Lung, Killer Cells, Natural, Transcriptome, bronchopulmonary dysplasia, adrenomedullin, RNA-seq, natural killer cells Abstract Bronchopulmonary dysplasia (BPD) is a chronic lung disease commonly affecting premature infants, with limited therapeutic options and increased long-term consequences.
Leveraging Integrated RNA Sequencing to Decipher Adrenomedullin’s Protective Mechanisms in Experimental Bronchopulmonary Dysplasia
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Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2
Highlights • Unipotent hair-cell progenitors (UHCPs) initiate Emx2 expression • Emx2 expression symmetry is broken between sibling hair cells • Notch1a-activity-mediated symmetry breaking is stochastic • Anatomical and genetic asymmetries are separable Summary Most plane-polarized tissues are formed by identically oriented cells [, ].
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