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Sudhish A. Devadiga on Muck Rack

Sudhish A. Devadiga

As seen in: MDPI, BioRxiv, The Journal of Clinical Investigation
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Articles

A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies

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By Xiaolei Liu, Sudhish A. Devadiga, Robert Stanley, Ryan Morrow
| The Journal of Clinical Investigation
ResearchHematologyOncology Open Access | 10.1172/JCI175619 J Clin Invest. https://doi.org/10.1172/JCI175619. Copyright © 2024, Liu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Splicing factor mutations are common in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), but how they alter cellular functions is unclear.
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A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies

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By Xiaolei Liu, Sudhish A. Devadiga, Robert Stanley, Ryan Moroow
| BioRxiv
Abstract Splicing factor mutations are common in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), but how they alter cellular functions is unclear. We show that the pathogenic SRSF2P95H/+ mutation disrupts the splicing of mitochondrial mRNAs, impairs mitochondrial complex I function, and robustly increases mitophagy.
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The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish

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By Xiaolei Liu, William Jones, Mathieu Quesnel-Vallières, Sudhish A. Devadiga
| MDPI
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