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Sudipta Bar

As seen in: Nature, Cell Press
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Articles

Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction - Nature Metabolism

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By Sudipta Bar, Kenneth Wilson, Eric B. Dammer, Jordan Burton, Samah Shah, Anja Holtz, Jennifer Beck, Ananth Shantaraman, Nicholas T. Seyfried, Birgit Schilling, Lisa M. Ellerby
| Nature Verified
Abstract Tauopathies encompass a range of neurodegenerative disorders, such as Alzheimer’s disease (AD) and frontotemporal lobar degeneration with tau inclusions (FTLD-tau), for which there are currently no successful treatments. Here, we show impaired glycogen metabolism in the brain of a tauopathy Drosophila melanogaster model and people with AD, indicating a link between tauopathies and glycogen metabolism.
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OXR1 maintains the retromer to delay brain aging under dietary restriction - Nature Communications

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By Kenneth Wilson, Sudipta Bar, Eric B. Dammer, Joanna Bons, Grace Qi Verified, Akos Gerencser, Geetanjali Chawla, Philippe M Campeau, Hugo J. Bellen, Birgit Schilling, Nicholas T. Seyfried, Lisa M. Ellerby
| Nature Verified
Abstract Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediated lifespan extension in female flies. We found that mtd/OXR1 expression declines with age and it interacts with the retromer, which regulates trafficking of proteins and lipids.
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Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster - Nature Communications

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By Brian A Hodge, Geoffrey T. Meyerhof, Subhash D. Katewa, Ting Lian, Charles T. Lau, Sudipta Bar, Nicole Leung, Menglin Li, David Li-Kroeger, Simon Melov, Birgit Schilling, Pankaj Kapahi
| Nature Verified
Abstract Many vital processes in the eye are under circadian regulation, and circadian dysfunction has emerged as a potential driver of eye aging. Dietary restriction is one of the most robust lifespan-extending therapies and amplifies circadian rhythms with age. Herein, we demonstrate that dietary restriction extends lifespan in Drosophila melanogaster by promoting circadian homeostatic processes that protect the visual system from age- and light-associated damage.
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