Sudipto Basu

Keywords 3′ UTR intrinsically disordered regions protein folding co-translational transcription factor chromatin regulator RNA–IDR interaction RNA-based chaperone activity RNA multivalency hydrophobic clusters mesh-like condensates crosslinking mass spectrometry Get full text access Log in, subscribe or purchase for full access. References 1. Lianoglou, S. ∙ Garg, V. ∙ Yang, J.L. ... Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression Genes Dev.

Extensive research has highlighted the role of codon composition in regulating co-translational mRNA decay. Translational efficiency is often measured using a codon usage metric like the codon adaptation index (CAI), while mRNA stability is assessed through sequence- and structure-dependent metrics such as codon stabilization coefficient and internal unstructured segments (IUS).

Abstract More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3.