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Sujina Mali on Muck Rack

Sujina Mali

As seen in: Cell Press
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Articles

ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors

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By Richard Marshall, Zhihua Hua, Sujina Mali, Fionn McLoughlin
| Cell Press Verified
(Cell 177, 766–781.e1–e24; April 18, 2019) Our paper reported a new family of autophagy adaptors and receptors that use a ubiquitin-interacting motif (UIM)-related sequence to interact with the autophagic vesicle docking protein ATG8 and described the autophagic degradation of dysfunctional CDC48 complexes that use receptors within this family. We subsequently became aware of errors in Figures 7 and S1.
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ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors

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By Richard Marshall, Zhihua Hua, Sujina Mali
| Cell Press Verified
Highlights • A new binding site for autophagy adaptors and receptors was discovered on ATG8 • This site engages UIM-like sequences rather than the canonical ATG8-interacting motif • UIM-type autophagy adaptors and receptors can be found in plants, yeast, and humans • UIM-containing UBX domain proteins mediate autophagic clearance of CDC48/p97 Summary During autophagy, vesicle dynamics and cargo recruitment are driven by numerous adaptors and receptors that become tethered to the phagophore...
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