Sun Joo Cha on Muck Rack

Sun Joo Cha

As seen in: Cell Press
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Articles

Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models

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By Sun Joo Cha, Seongsoo Lee, Hyun-Jun Choi, Yu-Mi Jeon
| Cell Press Verified
Highlights • GSTO suppresses FUS-induced neurotoxicity • GSTO inhibits the formation of cytoplasmic FUS aggregates in neurons • Glutathionylation decreases FUS solubility by promoting phase separation • GSTO regulates FUS liquid-liquid phase separation by reducing glutathionylation in vivo Summary Fused in sarcoma (FUS) is a DNA/RNA-binding protein that is involved in DNA repair and RNA processing.
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