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Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

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By Lydia Kalafati, Ioannis Kourtzelis, Jonas Schulte-Schrepping, Xiaofei Li, Anupam Sinha, Sevina Dietz, Aikaterini Hatzioannou, Tatyana Grinenko, Eman Hagag, Canan Has, Marina Nati, Sundary Sormendi, Ales Neuwirth
| ScienceDirect Verified
Under a Creative Commons license open access Highlights • Trained innate immunity (TII) promotes anti-tumor activity • TII is linked to transcriptomic and epigenetic rewiring of granulopoiesis • Trained granulopoiesis promotes an anti-tumor phenotype in neutrophils • Trained granulopoiesis might bear potential for cancer immunotherapy Summary Trained innate immunity, induced via modulation of mature myeloid cells or their bone marrow progenitors, mediates sustained increased responsiveness to...
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