Suneel Apte

2PCA 2-pyridinecarboxaldehyde ADAM A disintegrin and metalloprotease domain ADAMTS A disintegrin-like and metalloprotease domain with thrombospondin type 1 motif CHA-FRADIC charge-based fractional diagonal chromatography CHAMP-N chromatographic amplification of protein N-terminal peptides CHOPPER chemical enrichment of protease substrates with purchasable elutable reagents CHOPS chemical enrichment of protease substrates COFRADIC combined fractional diagonal chromatography CPB-ChaFRADIC...

Abstract The hypothalamic arcuate nucleus (ARH) contains neurons vital for maintaining energy homeostasis that sense and respond to changes in blood-borne metabolic hormones. Despite its juxtaposition to the median eminence (ME), a circumventricular organ lacking a blood-brain barrier and thus exposed to circulating molecules, only a few ventral ARH neurons perceive these extravasating metabolic signals due to a poorly understood ME/ARH diffusion barrier.

A group of Cleveland Clinic researchers has identified how the proteases ADAMTS9 and ADAMTS20 contribute to embryonic development and how defects in these enzymes lead to serious birth defects. Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission.