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Sungtaek Oh

As seen in: Nature, Wiley Online Library, MDPI, BioRxiv, Cell Press
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Articles

TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling

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By Daein Kim, Ragini Bhargava, Shih-Chun Wang, Wei-Che Tseng, Doohyung Lee, Riya Patel, Sungtaek Oh, Baylee Smith, MINKYU KIM, Chan Hyun Na, Roderick J. O’Sullivan, Kyle Miller
| Cell Press Verified
Keywords TRIM24 BLOCK-ID replication stress ALT telomeres SUMOylation chromatin acetylation p300 PML Introduction Faithful transmission of genetic and epigenetic material in eukaryotes requires the assembly of replicated DNA into chromatin.1 Histones, the building blocks of chromatin, are highly modified by post-translational modifications (PTMs) that govern many cellular functions, including during DNA replication.
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Myeloid lineage C3 induces reactive gliosis and neuronal stress during CNS inflammation - Nature Communications

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By Matthew Smith, Marjan Gharagozloo, Sungtaek Oh, Martina Absinta, Daniel S. Reich, Donald J. Zack, Thomas Garton, Ajay Kesharwani, Chan-Hyun Na
| Nature Verified
Abstract Complement component C3 mediates pathology in CNS neurodegenerative diseases. Here we use scRNAseq of sorted C3-reporter positive cells from mouse brain and optic nerve to characterize C3 producing glia in experimental autoimmune encephalomyelitis (EAE), a model in which peripheral immune cells infiltrate the CNS, causing reactive gliosis and neuro-axonal pathology.
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Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid using mass spectrometry-based proteomics

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By Yura Jang, Sungtaek Oh, Anna Hall, Zhen Zhang
| BioRxiv
Abstract Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that is often misdiagnosed as Parkinson's Disease (PD) because of shared symptoms. PSP is characterized by the accumulation of tau protein in specific brain regions, which results in loss of balance, gaze impairment, and dementia. Diagnosing PSP is often challenging, and there's a significant demand for reliable biomarkers.
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