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Susana C. Rosa

As seen in: Cell Press
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Articles

Re-Use of Caco-2 Monolayers for a Higher Throughput Assessment of Drug Permeability - Methodology and Validation for Passive Permeation

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By Susana C. Rosa, Lino Ferreira, Maria Moreno, Cristiana L. Pires
| preprints.org
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 29 May 2024 / Approved: 30 May 2024 / Online: 30 May 2024 (13:45:41 CEST) Pires, C. L.; Rosa, S.; Batista de Carvalho, A. L. M.; Ferreira, L.; Marques, M. P. M.; Moreno, M. J. Re-Use of Caco-2 Monolayers for a Higher Throughput Assessment of Drug Permeability – Methodology and Validation for Passive Permeation. Preprints 2024, 2024052057. https://doi.org/10.20944/preprints202405.2057.v1 Pires, C.
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Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells

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By Doctoral Programme, Catarina Praça, Susana C. Rosa, Emmanuel Sevin
| Cell Press Verified
Highlights • Derivation of BCLECs from iPSCs in chemically defined medium in two steps • Specification of EPCs into BCLECs requires the activation of VEGF, Wnt3a, and RA • Fibronectin seems a sufficient substrate for the specification of EPCs into BCLECs Summary The derivation of human brain capillary endothelial cells is of utmost importance for drug discovery programs focusing on diseases of the central nervous system.
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