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Articles by Susanne Bäck
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome
Highlights • High-throughput screening identifies stabilizers of the resident ER proteome • Several FDA-approved drugs stabilize the ER proteome during ER calcium depletion • Bromocriptine is a top hit and does not act through dopamine receptors • Bromocriptine is efficacious in disease models associated with calcium dysfunction Summary Endoplasmic reticulum (ER) dysregulation is associated with pathologies including neurodegenerative, muscular, and diabetic conditions.
Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats
Highlights • Methods are described for cell-specific genome modification in the adult rat brain • Transgenic rats were engineered to express Cre-dependent Cas9 or Cas9 nickase • A Cre driver rat for dopaminergic neurons and an mCherry Cre reporter rat were made • The first transgenic rat made by CRISPR and spermatogonial stem cells is described Summary Historically, the rat has been the preferred animal model for behavioral studies.
KDEL Receptors Are Differentially Regulated to Maintain the ER Proteome under Calcium Deficiency
Introduction The endoplasmic reticulum (ER) lumen is a site of essential cellular functions including lipid metabolism, calcium storage, and protein folding and trafficking ( Schwarz and Blower, 2016 The endoplasmic reticulum: structure, function and response to cellular signaling.Cell. Mol. Life Sci. 2016; 73: 79-94 ).
Longitudinal monitoring of Gaussia and Nano luciferase activities to concurrently assess ER calcium homeostasis and ER stress in vivo
The endoplasmic reticulum (ER) is essential to many cellular processes including protein processing, lipid metabolism and calcium storage. The ability to longitudinally monitor ER homeostasis in the same organism would offer insight into progressive molecular and cellular adaptations to physiologic or pathologic states, but has been challenging.
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