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Susanne Stefanie Babl on Muck Rack

Susanne Stefanie Babl

As seen in: Cell Press
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The Spatial Extent of Optogenetic Silencing in Transgenic Mice Expressing Channelrhodopsin in Inhibitory Interneurons

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By Susanne Stefanie Babl, Brian Paul Rummell, Torfi Sigurdsson
| Cell Press Verified
Highlights • Light delivery in VGAT-ChR2 mice causes spatially extensive inhibition • Even low light intensities can cause inhibition beyond the targeted brain region • This effect is consistent throughout various cortical and subcortical regions • Virus-mediated expression of an inhibitory opsin allows for region-specific silencing Summary Optogenetic stimulation of inhibitory interneurons has become a commonly used strategy for silencing neuronal activity.
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