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Sutapa Chakrabarti on Muck Rack

Sutapa Chakrabarti

As seen in: Cell Press
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Articles

Intrinsically disordered regions in eukaryotic mRNA decay pathways

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By Sarah Lewandowski, Sutapa Chakrabarti, Lea Sophie Pommerening
| Cell Press Verified
Keywords conformational flexibility networks SLiMs CCR4–NOT Dcp2 UPF1 Dynamic assembly of messenger ribonucleoprotein particles in eukaryotic gene expression Messenger RNA (mRNA) relays genetic information from DNA to proteins, serving as a conduit for gene expression. Initially described as an unstable intermediate necessary for protein synthesis, mRNA has emerged as a central regulator of gene expression in all forms of life.
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One enzyme, many substrates: How the vaccinia virus enzyme D9 decaps host and viral mRNAs alike

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By Vincent D. Maciej, Freie Universität Berlin, Sutapa Chakrabarti
| Cell Press Verified
The decapping enzyme D9 acts on host mRNA and viral double-stranded RNA to promote viral replication in host cells. In this issue of Structure,present crystal structures of mGDP-bound D9 to highlight how a conventional fold is adapted to target a wide variety of RNA substrates.
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