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Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Surgical trauma can result in hemorrhage that is difficult to clinically manage, especially for patients on antiplatelet therapy. Wang et al. present a high phosphatidylserine–exposed procoagulant platelet (hPPL) derivative to address this difficulty.
Personalized 3D Vaccine Integrates Immunotherapy and Antiangiogenic Therapy to Prevent Oral Squamous Cell Carcinoma Recurrence
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202417708-sup-0001-SuppMat.docx6.2 MB Supporting Information References 1, , , , , , CA. Cancer. J. Clin. 2020, 70, 313. 2, , , , , , , , , , , , Cancer. Res. 2023, 83, 1459. 3, , , , , , , , , , , , , , , Nat. Nanotechnol. 2019, 14, 89. 4, , , , , , , , , , Nat. Biomed. Eng. 2022, 6, 32. 5, , , , , Nat. Rev. Clin. Oncol. 2021, 18, 527. 6, , , , , , , , , , , , , , , , , , , , Nat. Commun. 2022, 13, 5378.
Selective apoptosis of tumor-associated platelets boosts the anti-metastatic potency of PD-1 blockade therapy
Keywords tumor-associated platelets PD-1 blockade therapy polymeric nanomedicine PD-1 response improvement platelet-mediated immunosuppression platelet modulation Introduction Metastasis, a hallmark of cancer, stands as the leading cause of cancer-related deaths and remains a major challenge for cancer treatment.1 The interaction between programmed cell death protein ligand-1 (PD-L1) on tumor cells and the immune checkpoint programmed cell death protein-1 (PD-1) on T cells aids tumor cells in...
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