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Articles by Sylvain Sebert
A Bayesian life-course linear structural equations model (BLSEM) to explore the development of body mass index (BMI) from the prenatal stage until middle age | International Journal of Obesity
Abstract We have developed a novel Bayesian Linear Structural Equations Model (BLSEM) with variable selection priors (available as an R package) to build directed acyclic graphs to delineate complex variable associations and pathways to BMI development. Conditional on standard assumptions used in causal inference, the model provides interpretable estimates with uncertainty for natural direct, indirect (mediated) and total effects.
A framework for conducting GWAS using repeated measures data with an application to childhood BMI - Nature Communications
Abstract Genetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to evaluate trajectories of change in traits, and estimates phenotypes to identify age-varying genetic effects in GWAS.
Evaluation and comparison of nine growth and development-based measures of pubertal timing - Communications Medicine
Abstract Pubertal timing is heritable, varies between individuals, and has implications for life-course health. There are many different indicators of pubertal timing, and how they relate to each other is unclear. Our aim was to quantitatively compare nine indicators of pubertal timing.
Epigenetic signature of very low birth weight in young adult life - Pediatric Research
Abstract Globally, one in ten babies is born preterm (<37 weeks), and 1–2% preterm at very low birth weight (VLBW, <1500 g). As adults, they are at increased risk for a plethora of health conditions, e.g., cardiometabolic disease, which may partly be mediated by epigenetic regulation. We compared blood DNA methylation between young adults born at VLBW and controls.
Cognition, mental health and quality of life amongst siblings of preterm born children: A systematic review
CASP Critical Appraisal Skills Programme ELBW extremely low birthweight NICU neonatal intensive care unit PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analysis PROSPERO International Prospective Register of Systematic Reviews VLBW low-birthweight subgroups include very low birthweight WEIRD western, educated, industrialised, rich, democratic countries This systematic review was designed to assess the evidence on cognition, mental health and quality of life in term-born...
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth - Nature Genetics
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Abstract A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1.
By Robin Beaumont, Christopher Flatley, Marc Vaudel, JING CHEN, Gunn-Helen Moen, Line Skotte, Øyvind Helgeland, Pol Sole-Navais, Karina Banasik, Clara Albiñana, Justiina Ronkainen, Katerina Trajanoska, David Westergaard, Sundararajan Srinivasan, José Ramón Bilbao, Catherine Allard, Teemu Kuulasmaa, Frédérique White, Haoxiang Cheng, Ke Hao, Ole A. Andreassen, Bjørn Olav Åsvold, Ben Michael Brumpton, Søren Brunak, Jonas Bybjerg-Grauholm, Paul Elliott, Christian Erikstrup, Marisa Estarlich Estarlich, Frank Geller, Jakob Grove, David M. Hougaard, Eero Kajantie, Mette Nyegaard, Ole Birger Pedersen, Fernando Rivadeneira, Sylvain Sebert, Camilla Stoltenberg, Bjarni J Vilhjálmsson, Cristen J. Willer, Timo A Lakka, Torben Frøstrup Hansen, Ewan R Pearson, Sisse R. Ostrowski, Craig E Pennell, Janine F. Felix, Andrew T. Hattersley, Deborah A. Lawlor, Thomas Werge, Henriette Svarre Nielsen, David Evans, Bo Jacobsson, Marjo-Riitta Järvelin, Marie-France Hivert, Stefan Johansson, Rachel M Freathy, Bjarke Feenstra, Marika Groleau, Dorte Gybel-Brask
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Vitamin D Status in Women with a History of Infertility and Decreased Fecundability: A Population-Based Study
1. Introduction Reproductive problems, such as infertility and prolonged time to pregnancy as well as insufficient vitamin D status, are common in Nordic countries [1,2,3]. Since vitamin D receptors and enzymes linked to vitamin D metabolism have been found in the pituitary gland, uterus, ovaries and placenta in women, a connection between vitamin D status and endocrinological and reproductive functions has been suggested [4,5].
Genetic fine-mapping from summary data using a non-local prior improves detection of multiple causal variants
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Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity
Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity N. Maneka G. De Silva, Sylvain Sebert, Alexessander Couto Alves, Ulla Sovio, Shikta Das, Rob Taal, Nicole M. Warrington, Alexandra M. Lewin, Marika Kaakinen, Diana Cousminer, Elisabeth Thiering, Nicholas J. Timpson, Ville Karhunen, Tom Bond, Xavier Estivill, Virpi Lindi, Jonathan P. Bradfield, Frank Geller, Lachlan J. M. Coin, Marie Loh, Sheila J. Barton, Lawrence J.
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