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Articles by Sylvia Wong
Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism
Abstract Interleukin-10 (IL-10) is a central anti-inflammatory cytokine that suppresses immune responses in myeloid cells but can also activate T cells, limiting its therapeutic use in chronic inflammatory diseases owing to narrow efficacy windows and dose-limiting toxicities1,2,3,4,5. Here we show that myeloid and T cells differ in their dependence on JAK-family kinase pairing for IL-10 signalling and function.
Teaching AI to Help, Not Harm, Young Minds
Artificial intelligence (AI) is rapidly reshaping how young people learn, connect, and experience the world. As devices become constant companions, young people are reporting increased loneliness, digital fatigue, and pressures amplified by always-on social media. Studies indicate that increased screen time is linked to a higher risk of developing mental health problems, sleep disruptions, and up to double the risk of anxiety and depression among young people.
Can youth-centred sexual and reproductive health self-care and contraceptive innovation address unintended pregnancy among girls and young women? Some reflections from Asia and the Pacific
Across Asia and the Pacific, girls and young women continue to experience high unmet needs for sexual and reproductive health (SRH) services, and subsequently face a range of poor health and social outcomes—including unintended pregnancy. We need to transform current approaches to address and prevent early and unintended pregnancy to more effectively respond to the lived realities of girls and women in the region and overcome the substantial barriers they face seeking SRH care.
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How Backbone Connect Accelerated Growth through Sales and Marketing Alignment
There’s no doubt big data has hit B2B marketing, with brands using (and generating) more customer information than ever. And yet, compare your last B2B experience with the kind of personalisation you see as a consumer in your personal life, and it’s clear B2B has a long way to go.
The prevalence and predictors of mental health diagnoses and suicide among U.S. college students: Implications for addressing disparities in service use - Liu - - Depression and Anxiety - Wiley Online Library
The college years represent a period of increased vulnerability for a wide range of mental health (MH) challenges. The onset of common psychiatric conditions occurs during this period of development. Increases in depression, anxiety, and suicidality among U.S. college students have been observed. This study identified prevalence and correlates of MH diagnoses and suicidality in a recent sample of U.S. college students.
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