Szczepan Baran

Get more Drug Discovery insight with our FREE newsletter Newsletter | September 8, 2026 Unlocking Challenging Targets with Macrocycle DNA-Encoded Libraries What if the next breakthrough target requires more than a conventional small molecule? Explore how macrocycle DNA-encoded libraries are opening new paths to challenging drug targets. This X-CHEM webinar will reveal how macrocycles expand chemical space, uncover differentiated hits, and generate insights that can accelerate discovery.

“Insanity is doing the same thing over and over and expecting different results” is a quote often attributed to Albert Einstein, and a sentiment that should resonate with any veteran of the pharmaceutical or biotech industries. The drug discovery and development process has been fundamentally flawed and dysfunctional for decades, with many years and much money wasted on expensive and often non-translational animal testing.

Introduction The use of sterile male mice to induce pseudopregnancy in female mice assigned for the implantation of embryos is a vital component in the production of Genetically Altered Animals (GAA). Usually the male is vasectomized, which is a surgical procedure under general anesthesia, with time required for the male to recover and the spermatozoa count to drop to zero.