Skip To Main Content
Sze Man Chan on Muck Rack

Sze Man Chan

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Sze Man

Contact Sze Man, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Tumor-derived annexin A1 drives lenvatinib resistance by regulating SOX2/STAT3/S100A6 feedback loop and M2 macrophage polarization in hepatocellular carcinoma

|
By Ki Chau, Yi Chen, Gregory Kenneth Muliawan, Yuan Z. Gao, Qian Yu, Ming Liu Verified, Xiao Wu, Jin Ding, Xin Wang, Stephanie Ma, Sze Man Chan
| Nature Verified
Abstract Lenvatinib has been approved by the FDA as a front-line treatment for advanced hepatocellular carcinoma (HCC), but its survival benefits are limited by acquired drug resistance. In this study, we investigate the mechanisms underlying lenvatinib resistance in HCC by establishing lenvatinib-resistant (LenR) patient-derived tumor xenograft (PDTX) and analyzing their genetic profiles via single-cell RNA sequencing (scRNA-seq).
Open in Who Shared Issue with article?
See all 1 articles