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Abstract Chimeric antigen receptor-modified T cell (CAR-T) immunotherapy has revolutionised blood cancer treatment. Parsing the genetic underpinnings of T cell quality and CAR-T efficacy is challenging. Transcriptomics inform CAR-T state, but the nature of dynamic transcription during activation hinders identification of transiently or minimally expressed genes, such as transcription factors, and over-emphasises effector and metabolism genes.
The construction industry has witnessed an increasing adoption of robots in a spectrum of tasks, with the goal of enhancing the efficiency, safety, and productivity of construction operations [1], such as the bricklaying robot [2], robotic welding [3], and UAV/UGV for inspection [4].
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