Taesun Yoo

Abstract Tuberous Sclerosis Complex (TSC) is a genetic neurodevelopmental disorder associated with early onset epilepsy, intellectual disability and neuropsychiatric disorders. A hallmark of the disorder is cortical tubers, which are focal malformations of brain development that contain dysplastic cells with hyperactive mTORC1 signaling. One barrier to developing therapeutic approaches and understanding the origins of tuber cells is the lack of a model system that recapitulates this pathology.

Correction to: Molecular Psychiatry https://doi.org/10.1038/s41380-023-02129-5, published online 26 June 2023 Data availability RNA-Seq results from Adnp-HT mice were deposited in the GEO (Gene expression Omnibus) database at NCBI under the accession number of GSE213354. Total proteomics data were deposited to the ProteomeXchange database under the accession number of PXD036544 (total) and PXD037325 (PTM).

Abstract ADNP syndrome, involving the ADNP transcription factor of the SWI/SNF chromatin-remodeling complex, is characterized by developmental delay, intellectual disability, and autism spectrum disorders (ASD). Although Adnp-haploinsufficient (Adnp-HT) mice display various phenotypic deficits, whether these mice display abnormal synaptic functions remain poorly understood.